{"id":"W7116910413","doi":"10.1021/acs.jmedchem.5c02749","title":"Discovery of BE2012, a First-in-Class REV-ERBα/β Antagonist with Favorable Selectivity and Pharmacokinetics, and In Vivo Efficacy in Inducing Key Myogenic Factors for Muscle Repair upon Acute Muscle Injury","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals","keywords":"Antagonist; In vivo; ADME; Skeletal muscle; Antagonism; Myocyte; Downregulation and upregulation; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003564553,0.0008072816,0.0008461427,0.0004068893,0.0002477912,0.0006444649,0.000447427,0.0005014667,0.001227493],"category_scores_gemma":[0.0002499922,0.0002737611,0.0004831875,0.0003260091,0.0002339825,0.0004403086,0.0003494816,0.0008431898,0.00062952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005042131,"about_ca_system_score_gemma":0.0006146187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008725005,"about_ca_topic_score_gemma":0.002639999,"domain_scores_codex":[0.999853,0.00002605102,0.000007605039,0.00002647666,0.00004757254,0.00003921885],"domain_scores_gemma":[0.9999307,0.000007224074,0.00001858016,0.000004814832,0.00001532848,0.00002325679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008391187,0.0008119834,0.0005270205,0.0004530606,0.0001242037,0.0006000632,0.00007927039,0.003663177,0.9538338,0.001281166,0.001829303,0.03595784],"study_design_scores_gemma":[0.00152805,0.01258823,0.003665403,0.00007581229,0.0003517591,0.002917786,0.00007461337,0.008803728,0.9132143,0.0006331446,0.05603023,0.0001170302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9198778,0.02849308,0.03290593,0.001176755,0.0001854712,0.0009581195,0.002357605,0.0004987644,0.01354653],"genre_scores_gemma":[0.9515108,0.01874676,0.01634655,0.0007317815,0.00004663525,0.0002253333,0.00324878,0.00007516136,0.009068241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001227493,"threshold_uncertainty_score":0.004106402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006155114243838708,"score_gpt":0.2631795541642115,"score_spread":0.2570244399203728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}