{"id":"W7116911933","doi":"10.3390/biom16010020","title":"Structural and Computational Insights into the Angiotensin II Type 1 Receptor: Advances in Antagonist Design and Implications for Hypertension Therapy (2020–2024)","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Angiotensin II; Angiotensin II receptor type 1; Heart failure; Blood pressure; Antagonist; Renin–angiotensin system; In vivo; Key (lock)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003512934,0.000783107,0.001079477,0.0003846652,0.0003226293,0.0007630737,0.0007453372,0.0008532323,0.004106856],"category_scores_gemma":[0.0005835726,0.0002933843,0.0008428712,0.0004492505,0.0002970777,0.0008090009,0.0005056298,0.0008329715,0.00080415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003597923,"about_ca_system_score_gemma":0.001094171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002249829,"about_ca_topic_score_gemma":0.003469327,"domain_scores_codex":[0.9998862,0.00003870025,0.000005050158,0.00001248687,0.00004037239,0.00001729068],"domain_scores_gemma":[0.9998773,0.00007216434,0.00001296758,0.000008998859,0.00001622649,0.00001230566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000388738,0.0003043808,0.002782632,0.003236302,0.0004828688,0.0007775617,0.0001347254,0.6832303,0.02004216,0.1517459,0.01535195,0.1215225],"study_design_scores_gemma":[0.0002193943,0.0005192559,0.001165019,0.0003357134,0.0002611553,0.0003731353,0.0001383609,0.8511707,0.003340624,0.07118449,0.07123894,0.0000532462],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.2720585,0.2369861,0.3406684,0.02012872,0.001681879,0.0002950164,0.005400823,0.001476473,0.1213041],"genre_scores_gemma":[0.6753691,0.1408727,0.1652608,0.002528608,0.0009713074,0.0005390942,0.004646611,0.0002933473,0.009518501],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004106856,"threshold_uncertainty_score":0.01373875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02356259025196056,"score_gpt":0.3060054274715069,"score_spread":0.2824428372195463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}