{"id":"W7116918739","doi":"10.1021/acs.analchem.5c05529","title":"Simultaneous Detection of SARS-CoV-2 Nucleocapsid Protein and RNA by Aptamer-Based Proximity Ligation and Quantitative PCR","year":2025,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Aptamer; Proximity ligation assay; RNA; TaqMan; Ligation; Analyte; DNA; Real-time polymerase chain reaction; Multiplex","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001214531,0.0008204014,0.0005888023,0.0005343092,0.0002300661,0.0006452067,0.0005253369,0.0007515466,0.0009129098],"category_scores_gemma":[0.001221808,0.0004889215,0.0005350283,0.0002959052,0.0005370147,0.0005283811,0.0007796398,0.0008438982,0.0007899739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004752992,"about_ca_system_score_gemma":0.0003646711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000208725,"about_ca_topic_score_gemma":0.000550508,"domain_scores_codex":[0.9973126,0.000555363,0.0001438081,0.0008703024,0.0009391475,0.0001787343],"domain_scores_gemma":[0.9993831,0.0002543941,0.0001410921,0.00006839655,0.0001155403,0.000037425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003719322,0.00002680826,0.0001506485,0.00003082057,0.000006169364,0.00001931886,0.00001650664,0.0001885883,0.9965478,0.0000741954,0.00003075177,0.002871241],"study_design_scores_gemma":[0.000003914383,0.0001025879,0.0003545991,0.000003221911,0.000006316141,0.0000903718,0.000008640242,0.003076673,0.9955587,0.00004659814,0.0007405747,0.0000077793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5604844,0.00162686,0.430508,0.0002759603,0.0001000034,0.0006311735,0.0007892018,0.001596213,0.003988077],"genre_scores_gemma":[0.5908653,0.001174578,0.3980108,0.0002891515,0.00005025595,0.0008833777,0.001185824,0.0001290694,0.007411566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214531,"threshold_uncertainty_score":0.006423175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088977948017615,"score_gpt":0.2915661057689796,"score_spread":0.2806763262888035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}