{"id":"W7116939398","doi":"10.1002/art.70020","title":"Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target","year":2025,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China; Shanghai Municipal Health Commission","keywords":"Rheumatoid arthritis; Biomarker; Proteomics; Kinase; Arthritis; Biomarker discovery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004189838,0.0004777878,0.0004305099,0.0005516154,0.0001950112,0.0005654511,0.0002002526,0.0004111645,0.0007647812],"category_scores_gemma":[0.0004407955,0.0001376794,0.0004006611,0.0004538591,0.000243308,0.0002478245,0.0002582579,0.0003300539,0.0002494503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002585477,"about_ca_system_score_gemma":0.0002291101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003195163,"about_ca_topic_score_gemma":0.0004120378,"domain_scores_codex":[0.9998185,0.00003075479,0.00001923707,0.00004863816,0.00005733747,0.00002563738],"domain_scores_gemma":[0.9997802,0.00004072552,0.0001079295,0.00001175604,0.00002948065,0.00002984648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001658678,0.00006402961,0.04356305,0.000261858,0.0001381222,0.0003135492,0.00005501294,0.0005436544,0.935668,0.00009217689,0.0002198988,0.01742205],"study_design_scores_gemma":[0.0002061155,0.001688041,0.532917,0.00008058947,0.0004370948,0.006484866,0.0002520073,0.01458877,0.4384657,0.0009053494,0.003905284,0.00006921317],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905058,0.004907939,0.003490387,0.0001443663,0.00001896798,0.00002066829,0.0004074254,0.00006507408,0.0004393173],"genre_scores_gemma":[0.9950603,0.0009684283,0.003210619,0.00007185463,0.00001938092,0.00001615323,0.0002824432,0.000006928666,0.0003640667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007647812,"threshold_uncertainty_score":0.00255847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143084802649545,"score_gpt":0.2639249885511187,"score_spread":0.2524941405246232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}