{"id":"W7116940050","doi":"10.1016/j.jbc.2025.111107","title":"Sphingosine-1-phosphate receptor 2 inhibition ameliorates familial exudative vitreoretinopathy models","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Receptor; Angiogenesis; Retinal; Gene knockdown; Small hairpin RNA; Receptor antagonist; G protein-coupled receptor; Knockout mouse","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498315,0.0004061871,0.0003386863,0.0003443121,0.0001574321,0.0001940804,0.0002997321,0.0004223736,0.001233135],"category_scores_gemma":[0.00008383512,0.000114811,0.000353997,0.00009202294,0.0001674443,0.0001760733,0.0001505769,0.0007779744,0.0002026348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002564838,"about_ca_system_score_gemma":0.0002579312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086456,"about_ca_topic_score_gemma":0.00233708,"domain_scores_codex":[0.999862,0.0000252181,0.00001498092,0.00002090534,0.00004553904,0.00003136022],"domain_scores_gemma":[0.9999251,0.000008775995,0.00002400346,0.000006566764,0.000009204253,0.00002634164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004243703,0.0002758013,0.0001985569,0.000102888,0.00002589874,0.0001887394,0.00002590403,0.0001645483,0.9941781,0.0001240478,0.0002705609,0.004020582],"study_design_scores_gemma":[0.0001970681,0.004075516,0.00654737,0.0000312128,0.00008362582,0.0007178916,0.0000670404,0.001940396,0.9786543,0.0001078947,0.007563149,0.0000144927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918013,0.003601576,0.001648373,0.000289034,0.00007455642,0.00004857715,0.0005398332,0.000228951,0.001767637],"genre_scores_gemma":[0.9914095,0.002521065,0.001912365,0.000132197,0.00001677966,0.00007424654,0.0007205275,0.00001591903,0.003197427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001233135,"threshold_uncertainty_score":0.004125237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448184367812164,"score_gpt":0.2470730543743868,"score_spread":0.2325912106962652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}