{"id":"W7116950454","doi":"10.1002/alz70862_109761","title":"Reactive Astrogliosis predicts Amyloid Accumulation before the Preclinical Stage of Alzheimer's Disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Astrogliosis; Disease; Neuroinflammation; Stage (stratigraphy); Amyloid (mycology); Function (biology); Astrocyte","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005130243,0.0006176043,0.0003591593,0.001226237,0.0005108694,0.0007698525,0.0002461556,0.0006780903,0.002461203],"category_scores_gemma":[0.000925854,0.0002825578,0.0002391475,0.0004043787,0.000295377,0.000382493,0.0003295581,0.000412647,0.0006063617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001917324,"about_ca_system_score_gemma":0.0001948707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001853615,"about_ca_topic_score_gemma":0.002074149,"domain_scores_codex":[0.999889,0.00001944928,0.00001794392,0.00002963179,0.00002205044,0.00002185811],"domain_scores_gemma":[0.9991152,0.0001113316,0.0003031001,0.00004608044,0.0001452042,0.0002791338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00326713,0.0002994508,0.9760371,0.00005546741,0.00007077542,0.0005511249,0.0001577871,0.000118872,0.0155772,0.00007031955,0.0003822048,0.003412498],"study_design_scores_gemma":[0.00001857032,0.0004374228,0.9967663,0.00001265051,0.00003820939,0.0009873973,0.0001023072,0.000219505,0.00106768,0.00007496439,0.000269978,0.00000498106],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979637,0.0004413932,0.0001358276,0.00002048379,0.00001205492,0.00001500141,0.0001453921,0.00001824637,0.00124795],"genre_scores_gemma":[0.9991434,0.000115501,0.0001641274,0.00001283297,0.00001289722,0.0000106535,0.0001819343,0.000003737535,0.0003550328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002461203,"threshold_uncertainty_score":0.008233547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05540162649546771,"score_gpt":0.3725486211130852,"score_spread":0.3171469946176175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}