{"id":"W7116961433","doi":"10.1016/j.annonc.2025.10.694","title":"981P Enozertinib (ORIC-114), a highly selective, brain penetrant EGFR and HER2 inhibitor, in patients with HER2 Exon 20 mutant NSCLC: Randomized dose optimization","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Daiichi-Sankyo","keywords":"Penetrant (biochemical); Mutant; Exon; Mutation; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001273982,0.001329023,0.001741276,0.0005137234,0.0002875098,0.001370593,0.0007871625,0.001138117,0.005246299],"category_scores_gemma":[0.0009140073,0.0006636072,0.001764337,0.0005294802,0.000877345,0.001211538,0.0004284095,0.003571463,0.0008683678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001321624,"about_ca_system_score_gemma":0.0009498369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001570243,"about_ca_topic_score_gemma":0.004099006,"domain_scores_codex":[0.9994206,0.0002780333,0.00003287232,0.00009022692,0.00005173027,0.0001265544],"domain_scores_gemma":[0.9996841,0.00007764614,0.00006856601,0.00002533359,0.00001810433,0.0001263376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9307325,0.004699617,0.001142182,0.0004402878,0.001294544,0.00004770355,0.00005775963,0.001651039,0.004659484,0.00039185,0.001587444,0.05329542],"study_design_scores_gemma":[0.8893515,0.09617642,0.005524565,0.00007158048,0.001377207,0.000095473,0.00005964227,0.001895994,0.001502873,0.0005888631,0.003307902,0.0000478959],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829234,0.005050202,0.001062321,0.001097631,0.0003731626,0.002296249,0.001367984,0.0002168115,0.005612147],"genre_scores_gemma":[0.9871774,0.002895198,0.001348719,0.001199697,0.0001634072,0.001421698,0.00121088,0.00005426315,0.004528711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005246299,"threshold_uncertainty_score":0.01755065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277304934096056,"score_gpt":0.3394166619055724,"score_spread":0.3266436125646118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}