{"id":"W7116973809","doi":"10.1002/alz70862_110035","title":"Genetic and Causal Insights Into White Matter Hyperintensities Across the Brain‐Body Axis","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; McGill University Health Centre; Mila - Quebec Artificial Intelligence Institute; Montreal Neurological Institute and Hospital; McGill University; University of Calgary; Université de Montréal; Institut Universitaire de Gériatrie de Montréal; Montreal Heart Institute","funders":"","keywords":"Hyperintensity; White matter; CADASIL; Single-nucleotide polymorphism; Neuroimaging; Association (psychology); Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001241389,0.0005127476,0.0003348795,0.001285741,0.0003460914,0.0006336579,0.0002688696,0.0002950885,0.001553607],"category_scores_gemma":[0.002434933,0.0001949609,0.0006450493,0.001687457,0.0006084907,0.0002749609,0.0007224745,0.0005091276,0.0001052076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446528,"about_ca_system_score_gemma":0.0003834756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004135278,"about_ca_topic_score_gemma":0.00520729,"domain_scores_codex":[0.9992888,0.0002601879,0.00004502085,0.0002451985,0.00009382882,0.00006693785],"domain_scores_gemma":[0.9981535,0.0009687839,0.0004632206,0.0002458228,0.00008806286,0.00008064388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001198567,0.00009587509,0.8711149,0.0002949116,0.0023071,0.001463465,0.001180668,0.006444147,0.06975025,0.004446739,0.0006554817,0.04104793],"study_design_scores_gemma":[0.00003193086,0.0000839009,0.9868019,0.00004137685,0.0006424668,0.0006307287,0.0002055428,0.003339754,0.002757812,0.004361429,0.001083118,0.00002006014],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874244,0.0009646016,0.009111881,0.0001954841,0.000007492463,0.00001892594,0.001516894,0.00005541764,0.0007048312],"genre_scores_gemma":[0.9941002,0.0003522252,0.004670274,0.00005460195,0.00001163522,0.00002222768,0.0006451884,0.00001526179,0.0001284856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004135278,"threshold_uncertainty_score":0.008222401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455197659408705,"score_gpt":0.3046302037067951,"score_spread":0.2900782271127081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}