{"id":"W7116987910","doi":"10.1007/s13402-025-01150-w","title":"PARP7 and aryl hydrocarbon receptor differentially regulate mammary cancer cell proliferation and STING-induced type I interferon signalling","year":2025,"lang":"en","type":"article","venue":"Cellular Oncology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Universitetet i Oslo","keywords":"Aryl hydrocarbon receptor; Cell growth; Signalling; Cell culture; Signalling pathways; Cancer cell lines; Interferon; Receptor; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325362,0.0002298026,0.0003942923,0.0001282613,0.0001831086,0.00003478249,0.0001547244,0.00046411,0.0002677729],"category_scores_gemma":[0.00004974155,0.0002121273,0.000043512,0.00009398576,0.0001373191,0.00009258755,0.0002077999,0.0003495858,0.00002569999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001290226,"about_ca_system_score_gemma":0.000197141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001640598,"about_ca_topic_score_gemma":0.000121664,"domain_scores_codex":[0.9985574,0.000320653,0.0003531852,0.000414682,0.000025357,0.0003287087],"domain_scores_gemma":[0.9993991,0.0001600505,0.0001327994,0.0001950931,0.00008390399,0.0000290112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001235185,0.00009782649,0.0004444858,0.00006765049,0.0001342294,0.0000059146,0.0004874541,0.0000016327,0.9804161,0.0004209225,0.0006386808,0.01604997],"study_design_scores_gemma":[0.001571273,0.001324537,0.0007398234,0.0001146513,0.00009751092,0.00001459991,0.0001851204,0.0002700116,0.977695,0.0001301194,0.01762868,0.0002286959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796496,0.0153828,0.0006728352,0.0006185923,0.001592434,0.0003330103,0.000003223099,0.00006930067,0.001678185],"genre_scores_gemma":[0.9889207,0.001292571,0.0000730125,0.0002738118,0.0000427493,0.00003706306,0.00006188766,0.00001820401,0.009279996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01698999,"threshold_uncertainty_score":0.8650301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364023572728204,"score_gpt":0.2590991002092376,"score_spread":0.2454588644819556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}