{"id":"W7117002553","doi":"10.1016/j.annonc.2025.10.681","title":"LBA13 Enozertinib (ORIC-114), a highly selective, brain penetrant EGFR and HER2 inhibitor, in EGFR Exon 20 mutant NSCLC: Randomized dose optimization and CNS activity","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Daiichi-Sankyo","keywords":"Penetrant (biochemical); Mutant; Exon; Mutation; Dose dependence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00134375,0.001102866,0.001874037,0.0005586148,0.0002899579,0.001307586,0.0008868813,0.00114865,0.004326762],"category_scores_gemma":[0.0007979741,0.0005022603,0.001648528,0.0006090559,0.0007850362,0.000968547,0.0003093454,0.003429645,0.0007891362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00166073,"about_ca_system_score_gemma":0.001446677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002943134,"about_ca_topic_score_gemma":0.008698995,"domain_scores_codex":[0.9994803,0.0002384555,0.00003075139,0.00006530865,0.00005138371,0.0001339138],"domain_scores_gemma":[0.9996006,0.00008476753,0.00008284039,0.00002695439,0.00002703624,0.0001778458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.863229,0.008375032,0.001618963,0.0007012619,0.001799255,0.00009336881,0.00007589303,0.001938784,0.01035761,0.0005230011,0.003075926,0.1082118],"study_design_scores_gemma":[0.7783449,0.1957647,0.009775259,0.0001480363,0.00232066,0.0002728768,0.00009111234,0.002755308,0.004466869,0.000601785,0.005377905,0.00008064289],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811571,0.00878637,0.0008999194,0.0008868956,0.0002719659,0.001648268,0.001643827,0.0002405457,0.004465222],"genre_scores_gemma":[0.9851788,0.005651958,0.001305527,0.000954181,0.0001519485,0.0009888991,0.001678493,0.00006436372,0.004025966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004326762,"threshold_uncertainty_score":0.01447445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224528454844219,"score_gpt":0.3792311041842654,"score_spread":0.3567782586998435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}