{"id":"W7117100174","doi":"10.1016/j.vaccine.2025.128135","title":"Effect of Co-administration of the anthrax vaccine adsorbed, adjuvanted with ciprofloxacin or doxycycline on antibiotic pharmacokinetics and the vaccine immunogenicity: A phase 2 drug-vaccine interaction study","year":2025,"lang":"en","type":"article","venue":"Vaccine","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Biomedical Advanced Research and Development Authority; U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response","keywords":"Doxycycline; Ciprofloxacin; Pharmacokinetics; Antibiotics; Drug interaction; Drug-drug interaction; Pharmacokinetic interaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001485504,0.001142583,0.002270984,0.0003245509,0.0002234707,0.0008510472,0.0006557757,0.001214049,0.002760742],"category_scores_gemma":[0.002049813,0.0005923316,0.001389617,0.0002788087,0.0006406863,0.0009225431,0.0004497227,0.001851576,0.0004154294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005712144,"about_ca_system_score_gemma":0.0008780223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000496473,"about_ca_topic_score_gemma":0.000907094,"domain_scores_codex":[0.9988381,0.0005916257,0.00006200447,0.0002188911,0.0001173867,0.0001718804],"domain_scores_gemma":[0.9983903,0.0005868765,0.0004280132,0.0001140543,0.0001029222,0.0003778852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8067659,0.1064509,0.002691546,0.0007048781,0.001393116,0.0001343298,0.0001699226,0.001148871,0.04437291,0.00007696611,0.0003451164,0.03574562],"study_design_scores_gemma":[0.03399646,0.9547887,0.004312322,0.00001614208,0.00047764,0.00004746162,0.00002743043,0.0006734525,0.005090974,0.00003159962,0.0005167879,0.00002101096],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983796,0.0006700565,0.0001675272,0.00004940838,0.00005571155,0.0003571429,0.00008475536,0.000008799359,0.0002270043],"genre_scores_gemma":[0.9961308,0.0009081991,0.0006315849,0.0001243023,0.0001287953,0.0006192727,0.0001995729,0.00001062835,0.001246911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002760742,"threshold_uncertainty_score":0.009235561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007436318307978424,"score_gpt":0.338345195738582,"score_spread":0.3309088774306035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}