{"id":"W7117106431","doi":"10.1093/narmme/ugaf046","title":"Combination of vemurafenib, pleconaril, and AG7404 attenuates enterovirus replication <i>in vitro</i> and <i>in vivo</i>","year":2025,"lang":"en","type":"article","venue":"NAR Molecular Medicine","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Supercomputer Centre, Linköpings Universitet; Helse Midt-Norge; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Réseau de cancérologie Rossy; Helse Sør-Øst RHF; Norges Teknisk-Naturvitenskapelige Universitet","keywords":"Coxsackievirus; Enterovirus; Vemurafenib; Echovirus; Viral life cycle; Virus; Viral replication; Cell culture; Rhinovirus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049949,0.000319619,0.0003392743,0.0002379554,0.0001039283,0.0003008113,0.0002049715,0.000172823,0.001262282],"category_scores_gemma":[0.0001139579,0.00007341786,0.000204246,0.0001364408,0.0001342941,0.0001954321,0.0001255199,0.0004212704,0.0002342122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002335138,"about_ca_system_score_gemma":0.0002965567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007385722,"about_ca_topic_score_gemma":0.001887675,"domain_scores_codex":[0.9998933,0.00002510672,0.00001132638,0.0000124124,0.00001838789,0.0000394364],"domain_scores_gemma":[0.9999501,0.000009098688,0.000009638676,0.000005550651,0.000005116333,0.00002046764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005408415,0.001521858,0.001092213,0.000190908,0.00008752457,0.0001279824,0.00003325694,0.0008366804,0.9528788,0.0002202209,0.001350812,0.03625116],"study_design_scores_gemma":[0.0004342477,0.01477964,0.008849421,0.00001157903,0.00008616317,0.0004722039,0.00004790761,0.003402872,0.9650086,0.00005929311,0.006832348,0.00001576278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954147,0.001435873,0.0008397429,0.000102305,0.00005307834,0.00004599764,0.0002510448,0.0001177209,0.001739588],"genre_scores_gemma":[0.9971168,0.0005078159,0.0007758971,0.0000348922,0.00001391551,0.00003547383,0.0004113642,0.000007889584,0.001095897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262282,"threshold_uncertainty_score":0.004222751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077725305540851,"score_gpt":0.3084166402692566,"score_spread":0.2976393872138481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}