{"id":"W7117121405","doi":"10.1007/s11538-025-01574-3","title":"Immune Modulation in the Tumor Microenvironment: Bifurcation Analysis of Cancer-CTL-Monocyte Dynamics","year":2025,"lang":"en","type":"article","venue":"Bulletin of Mathematical Biology","topic":"Mathematical Biology Tumor Growth","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Science Foundation","keywords":"Allee effect; Immune system; Hopf bifurcation; Bifurcation; Cytotoxic T cell; Ordinary differential equation; Nonlinear system; Antigen presentation; Control theory (sociology); Immune surveillance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002114299,0.0002875671,0.0003876982,0.0004589752,0.0003243944,0.0005705925,0.0003339247,0.0005593174,0.001200837],"category_scores_gemma":[0.0005723701,0.0001389059,0.0004734563,0.0001982196,0.0004306029,0.0004199452,0.0004650845,0.0003208065,0.0001424232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007562894,"about_ca_system_score_gemma":0.000487896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002799832,"about_ca_topic_score_gemma":0.001079191,"domain_scores_codex":[0.9999371,0.00002162952,0.000002952065,0.00001021365,0.00001510523,0.00001292621],"domain_scores_gemma":[0.9998496,0.00005180002,0.00004521233,0.00001034539,0.00002728285,0.0000158634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0000669701,0.00004984086,0.002813493,0.00007416611,0.0000409396,0.0003850982,0.0001448237,0.8710882,0.02646575,0.09357464,0.000609184,0.004687021],"study_design_scores_gemma":[0.000002862203,0.000006651523,0.0002023455,0.000003171423,0.000003471864,0.00002198446,0.000009615203,0.9953751,0.0004328683,0.003801781,0.0001368919,0.000003340939],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6501392,0.0009758751,0.332139,0.0008765275,0.00006323867,0.00007659166,0.0001613072,0.0001972068,0.01537108],"genre_scores_gemma":[0.9938357,0.0001398402,0.004439501,0.00002998167,0.000008667605,0.00003253046,0.00001974026,0.000008997752,0.0014849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002799832,"threshold_uncertainty_score":0.005567014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618014834707256,"score_gpt":0.3026141442082642,"score_spread":0.2864339958611916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}