{"id":"W7117141376","doi":"10.1111/cts.70458","title":"Tutorial Drug–Drug Interactions","year":2025,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pharmacodynamics; Population; Categorical variable; Drug; Variation (astronomy); Drug development; Socioeconomic status","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003139112,0.002319674,0.00162652,0.00424013,0.001012105,0.004722189,0.002128687,0.006496823,0.08434622],"category_scores_gemma":[0.0139245,0.0005368129,0.001301311,0.002492222,0.002142786,0.007294085,0.002918917,0.008410389,0.04912938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002010127,"about_ca_system_score_gemma":0.001981057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087816,"about_ca_topic_score_gemma":0.001888615,"domain_scores_codex":[0.9972208,0.001016117,0.0002804991,0.0003130118,0.0009998579,0.000169664],"domain_scores_gemma":[0.9895047,0.007185253,0.0007530557,0.0003741325,0.001446583,0.0007362738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005197253,0.00003140261,0.0001308809,0.001406724,0.00002831957,0.000206759,0.00009328587,0.0001793029,0.0002221634,0.01778168,0.848039,0.1318284],"study_design_scores_gemma":[0.000005953166,0.0000255449,0.0001185559,0.0004274217,0.000008486189,0.0005613624,0.00002824619,0.00008174794,0.00004884834,0.00634985,0.9923355,0.000008489799],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.0007724369,0.4619165,0.01920956,0.1533045,0.1849307,0.0003078443,0.002488548,0.00203166,0.1750382],"genre_scores_gemma":[0.01053104,0.3248654,0.01897071,0.1878483,0.264386,0.0005039551,0.00250389,0.001030201,0.1893606],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.08434622,"threshold_uncertainty_score":0.2821662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1618331780815495,"score_gpt":0.5523489411735696,"score_spread":0.3905157630920201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}