{"id":"W7117141376","doi":"10.1111/cts.70458","title":"Tutorial Drug–Drug Interactions","year":2025,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pharmacodynamics; Population; Categorical variable; Drug; Variation (astronomy); Drug development; Socioeconomic status","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001734182,0.0001016131,0.0001554167,0.0001086332,0.0005203431,0.00003770372,0.0002548446,0.0000464002,0.0005031379],"category_scores_gemma":[0.0001441583,0.00008810739,0.00008339235,0.0004377934,0.001349608,0.0001719413,0.00005932906,0.0004957373,0.00004549431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005825484,"about_ca_system_score_gemma":0.0003067514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001138976,"about_ca_topic_score_gemma":0.0000195693,"domain_scores_codex":[0.9986777,0.0001609665,0.0003965219,0.0003505825,0.0001756012,0.0002386126],"domain_scores_gemma":[0.9986007,0.0009016122,0.00004936702,0.0000906141,0.0001232097,0.000234455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005497686,0.000957965,0.2784683,0.00003328719,0.0001629309,0.00001023661,0.0007223642,0.0004886215,0.01870719,0.2303499,0.01430751,0.455242],"study_design_scores_gemma":[0.001532015,0.000006949549,0.1311793,0.00000916223,0.00009620647,0.000003105359,0.00002028291,0.005886909,0.00362089,0.02565481,0.8318532,0.0001372215],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9214345,0.001309742,0.0005369824,0.01161003,0.0118998,0.0002287502,0.00005014554,0.00005269265,0.05287741],"genre_scores_gemma":[0.9933245,0.0003510272,0.0004546536,0.002515431,0.0006802187,0.00001140483,0.000004429628,0.000003147399,0.002655238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8175457,"threshold_uncertainty_score":0.5509008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1618331780815495,"score_gpt":0.5523489411735696,"score_spread":0.3905157630920201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}