{"id":"W7117145486","doi":"10.64898/2025.12.22.696083","title":"Outer Membrane Vesicles Hijack TIM-1 for Cellular Uptake","year":2025,"lang":"","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada); McMaster University","funders":"","keywords":"Internalization; Bacterial outer membrane; Lipopolysaccharide; Proinflammatory cytokine; Transmembrane protein; Effector; Vesicle; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002895239,0.0003296608,0.0003437557,0.0001686219,0.0001583355,0.0005909182,0.0001879441,0.0003566093,0.0007555006],"category_scores_gemma":[0.000132637,0.00009076396,0.0002780681,0.0001205336,0.000191218,0.0003650495,0.000262501,0.0003640191,0.000441003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004579867,"about_ca_system_score_gemma":0.0002202732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003745342,"about_ca_topic_score_gemma":0.0002981915,"domain_scores_codex":[0.9998249,0.00003087439,0.00001214786,0.00002559635,0.00005316271,0.00005334789],"domain_scores_gemma":[0.9999307,0.00001261891,0.00002175643,0.00001008802,0.00001323404,0.00001145121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005571826,0.0000121394,0.000278361,0.00003692458,0.000006654089,0.0000231674,0.000004998104,0.00006160342,0.9983398,0.0001444366,0.00006422895,0.0009719884],"study_design_scores_gemma":[0.000005938247,0.00008600962,0.001496669,0.0000054456,0.00001121924,0.00008433124,0.00001298191,0.0009566235,0.9956732,0.00007112524,0.001593758,0.000002624172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864879,0.003414534,0.007854334,0.0002872874,0.00004494488,0.00003393769,0.0005142094,0.0001399802,0.001222906],"genre_scores_gemma":[0.9934613,0.001172915,0.003281148,0.0001206636,0.000008417595,0.00002054985,0.00044837,0.00001074404,0.001475955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007555006,"threshold_uncertainty_score":0.003322959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116726300106062,"score_gpt":0.2186583863631376,"score_spread":0.2069857563525314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}