{"id":"W7117153883","doi":"10.64898/2025.12.19.695410","title":"Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma","year":2025,"lang":"en","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Institut universitaire de cardiologie et de pneumologie de Québec; Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; Health and Medical Research Fund; Fonds de Recherche du Québec - Santé; Manchester Biomedical Research Centre; INCLIVA Instituto de Investigación Sanitaria; Harvard University; Centre Hospitalier Universitaire de Nice; Ministry of Science and Technology, Taiwan; National Institute for Health and Care Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Yale University; Moffitt Cancer Center; Department of Health and Social Care; Ministry of Health and Welfare; Connaught Fund; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Adenocarcinoma; Genome instability; Lung; Lung cancer; Leverage (statistics); Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005590136,0.0001915995,0.0002890186,0.0009958185,0.0003958317,0.0009684238,0.0002278779,0.0003787836,0.001723],"category_scores_gemma":[0.001349026,0.0002302423,0.000310266,0.001064164,0.0002805275,0.000526535,0.0006100453,0.0006125243,0.0003255544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000362475,"about_ca_system_score_gemma":0.000363874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002952162,"about_ca_topic_score_gemma":0.005712498,"domain_scores_codex":[0.9997061,0.00006009695,0.00001769071,0.00009464168,0.00005133516,0.00007010023],"domain_scores_gemma":[0.9992952,0.0001896374,0.0002829253,0.0000636855,0.0000816421,0.00008688156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003505753,0.00005604013,0.8925876,0.0001376923,0.0002401373,0.0005972964,0.0004933171,0.001673226,0.07490942,0.001674401,0.0005390291,0.02674126],"study_design_scores_gemma":[0.000007370385,0.00009652309,0.982437,0.00003489945,0.00006356618,0.001088907,0.0008548042,0.004572772,0.005774446,0.001899049,0.00314656,0.00002418274],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943696,0.001247904,0.002422866,0.0002186181,0.000009121483,0.0000117342,0.0006897034,0.00003419593,0.0009963519],"genre_scores_gemma":[0.996511,0.0006695491,0.001519132,0.00007452426,0.00001030845,0.00000996134,0.0007248554,0.00001947188,0.0004610965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002952162,"threshold_uncertainty_score":0.005869925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009715324009590107,"score_gpt":0.2267932714406354,"score_spread":0.2170779474310453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}