{"id":"W7117159912","doi":"10.1093/brain/awaf472","title":"Treatment evolution in spinal muscular atrophy: insights from the SMArtCARE registry","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Biogen","keywords":"SMA*; Spinal muscular atrophy; Motor function; Milestone; Disease; Motor symptoms; Neuromuscular disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004399673,0.00009770579,0.0001453348,0.00007085354,0.00006521649,0.00001294834,0.00009307932,0.00006160683,0.0000301335],"category_scores_gemma":[0.0001243071,0.00006277527,0.0001063623,0.0002565619,0.000070347,0.0000145893,0.00003887132,0.0001271472,0.00002583962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632211,"about_ca_system_score_gemma":0.0002430614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133135,"about_ca_topic_score_gemma":0.0005489998,"domain_scores_codex":[0.9991751,0.0001137309,0.0001262838,0.0002383798,0.0001852929,0.0001612265],"domain_scores_gemma":[0.9994215,0.00005835387,0.00001701991,0.0004268078,0.00003015432,0.00004611503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002984084,0.001946632,0.5384322,0.0003229489,0.0009958744,0.002021131,0.002192721,0.00008763589,0.08568463,0.02003372,0.02446964,0.3208288],"study_design_scores_gemma":[0.002953095,0.0003369506,0.8974482,0.0001310017,0.00005285957,0.000007524236,0.0005660163,0.0001896916,0.0006021181,0.001483385,0.09615465,0.00007453102],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766674,0.007484482,0.0004075908,0.01171092,0.0001000297,0.0005423232,0.000004579143,0.00002044502,0.003062217],"genre_scores_gemma":[0.9971678,0.000119346,0.00008833693,0.0007473906,0.00009545423,0.00005892018,0.00003239765,0.0000085363,0.00168177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.359016,"threshold_uncertainty_score":0.2559901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447701831602506,"score_gpt":0.3025696059053217,"score_spread":0.2880925875892967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}