{"id":"W7117159912","doi":"10.1093/brain/awaf472","title":"Treatment evolution in spinal muscular atrophy: insights from the SMArtCARE registry","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Biogen","keywords":"SMA*; Spinal muscular atrophy; Motor function; Milestone; Disease; Motor symptoms; Neuromuscular disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003840418,0.0002023973,0.0006956948,0.002327951,0.0003761899,0.001404931,0.0005676026,0.0005503147,0.00128424],"category_scores_gemma":[0.01455579,0.0002235238,0.0006110162,0.005377817,0.0002773551,0.0011561,0.001291568,0.0005470894,0.0003361582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006257563,"about_ca_system_score_gemma":0.0008648125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006095118,"about_ca_topic_score_gemma":0.008115242,"domain_scores_codex":[0.9949378,0.002160254,0.0009415133,0.0009647299,0.0006608797,0.0003348781],"domain_scores_gemma":[0.9793246,0.004791948,0.011961,0.001867917,0.001429571,0.000625053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002222672,0.00001944875,0.9920858,0.00002931229,0.0001108779,0.00006619336,0.0001628121,0.0002601011,0.00007084654,0.0001160501,0.001037664,0.00581856],"study_design_scores_gemma":[0.00002560128,0.00009746991,0.9953787,0.00005538542,0.00008468196,0.0003573844,0.0003365873,0.0009117358,0.0001014062,0.0001195529,0.002516015,0.00001535632],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817339,0.001297905,0.0007077492,0.0004205421,0.00002008784,0.00003610336,0.01404485,0.0000333814,0.001705498],"genre_scores_gemma":[0.9841382,0.0006556113,0.0007645614,0.000130771,0.00002869919,0.00005831581,0.0140069,0.00002938265,0.0001875553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006095118,"threshold_uncertainty_score":0.02031028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447701831602506,"score_gpt":0.3025696059053217,"score_spread":0.2880925875892967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}