{"id":"W7117165262","doi":"10.1016/j.aohep.2025.102169","title":"Effect of pembrolizumab on viral hepatitis load and transaminases in advanced hepatocellular carcinoma","year":2025,"lang":"en","type":"article","venue":"Annals of Hepatology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Merck Sharp and Dohme","keywords":"Pembrolizumab; Hepatocellular carcinoma; Viral load; Viral hepatitis; Elevated transaminases; Hepacivirus; Hepatitis C virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000334284,0.0002676492,0.001055346,0.0004061289,0.00003069842,0.000003281052,0.00009236574,0.0002051821,0.00003446274],"category_scores_gemma":[0.0001611534,0.0002306984,0.0002158589,0.000300689,0.0002174127,0.00005459257,0.00003178469,0.0001688544,0.000003944077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003622112,"about_ca_system_score_gemma":0.0001659649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009221425,"about_ca_topic_score_gemma":0.00008119606,"domain_scores_codex":[0.9982669,0.0002813123,0.000531439,0.0003768958,0.0002021874,0.0003412517],"domain_scores_gemma":[0.9988981,0.0004322694,0.0001212022,0.0003352972,0.0001273528,0.00008576723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003532512,0.0002827122,0.9587247,0.0008945896,0.0001106944,0.0004677524,0.000130176,4.886794e-7,0.004901108,0.0005153648,0.0001088316,0.03033112],"study_design_scores_gemma":[0.006133691,0.00765278,0.2208511,0.0003594654,0.0002108223,0.0000463613,0.00001550653,0.002394735,0.7612011,0.0002364545,0.0007260363,0.0001718722],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898831,0.006494207,0.00001223122,0.0009866843,0.0000798227,0.0007753067,0.00002365686,0.00002156339,0.001723443],"genre_scores_gemma":[0.9982526,0.001095869,0.00005476226,0.0003285015,0.00001013011,0.00008133834,0.000033633,0.00001772712,0.0001254747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7563,"threshold_uncertainty_score":0.9407609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971382419660991,"score_gpt":0.3005657423177119,"score_spread":0.270851918121102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}