{"id":"W7117166066","doi":"10.64898/2025.12.23.696289","title":"Myelin Supports Cortical Circuit Function Underlying Skilled Movement","year":2025,"lang":"en","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Multiple Sclerosis Society; National Institutes of Health; National Science Foundation","keywords":"Myelin; Remyelination; Inhibitory postsynaptic potential; Motor cortex; Multiple sclerosis; Oligodendrocyte; Premovement neuronal activity; Primary motor cortex; Neurophysiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070675,0.0003731645,0.0001994136,0.0001852293,0.0002048914,0.0005142399,0.0003755814,0.0002979903,0.000638487],"category_scores_gemma":[0.0003528123,0.0001480242,0.0002019045,0.00007276019,0.0005474566,0.0004101967,0.0003414084,0.0003236401,0.0001175362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000687048,"about_ca_system_score_gemma":0.000472656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002557408,"about_ca_topic_score_gemma":0.002323418,"domain_scores_codex":[0.9999506,0.000009243863,0.000002736768,0.00001253742,0.00001350398,0.00001134571],"domain_scores_gemma":[0.9999114,0.00002314134,0.00002960138,0.00001144334,0.000008719514,0.00001570586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001826421,0.00004644535,0.006255224,0.0001799261,0.00006426362,0.0003462362,0.0001426998,0.212575,0.7313273,0.03161142,0.0003278106,0.01694108],"study_design_scores_gemma":[0.00003273357,0.0002306412,0.02076252,0.00002442375,0.00006783853,0.0003052594,0.0001549668,0.7820107,0.1574604,0.03720421,0.001719897,0.00002644033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398433,0.0002653576,0.05619815,0.0002092332,0.000009191075,0.00001169202,0.0001476476,0.0003781249,0.002937324],"genre_scores_gemma":[0.9974954,0.0001051083,0.002025992,0.000006421543,0.000001392289,0.000006101029,0.00003538844,0.000009455509,0.0003146261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002557408,"threshold_uncertainty_score":0.005085051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796252281121947,"score_gpt":0.2389008191120826,"score_spread":0.2109382963008631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}