{"id":"W7117234239","doi":"10.1002/alz70856_101070","title":"An Epi‐Metabolomics Approach for Studying Epigenetic and Metabolic changes in Alzheimer's Disease Brain","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"","keywords":"Epigenetics; Disease; Metabolomics; DNA methylation; Metabolite; Epigenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006851449,0.0005343874,0.0005201629,0.001470638,0.0003175212,0.0005950519,0.0003846566,0.0004183482,0.002216999],"category_scores_gemma":[0.0008120896,0.000269887,0.0008192933,0.00124813,0.0002418553,0.0003426186,0.0005396022,0.0006781333,0.0003641753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003838617,"about_ca_system_score_gemma":0.000603491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002144516,"about_ca_topic_score_gemma":0.005619176,"domain_scores_codex":[0.999792,0.00004734452,0.000009357321,0.00008131739,0.00004840564,0.0000215475],"domain_scores_gemma":[0.9998043,0.00006420274,0.00004063708,0.00002972959,0.00004224584,0.00001888045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008876717,0.0002958483,0.03447318,0.0007036243,0.001320167,0.0002713078,0.0002180086,0.008807025,0.8045884,0.004223666,0.002032914,0.1421782],"study_design_scores_gemma":[0.0001534635,0.001406357,0.4091731,0.0001169972,0.002134213,0.001607049,0.0003777354,0.1572894,0.361302,0.02327606,0.0428886,0.000274882],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2741801,0.005607434,0.6994666,0.0008843341,0.000165837,0.0004218347,0.01059369,0.001763659,0.006916387],"genre_scores_gemma":[0.5181631,0.003699339,0.4672267,0.0006535144,0.0001461488,0.0009246928,0.004300879,0.0002179503,0.004667616],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002216999,"threshold_uncertainty_score":0.007416606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02318143491400969,"score_gpt":0.2862011302832502,"score_spread":0.2630196953692405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}