{"id":"W7117239938","doi":"10.1002/alz70855_106838","title":"A rare variant polygenic risk score for Late‐Onset Alzheimer's Disease demonstrates trans‐ethnic predictive power","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Hamilton Regional Laboratory Medicine Program; McMaster University","funders":"","keywords":"Polygenic risk score; Disease; Predictive power; Multifactorial Inheritance; Genetic variants; Genetic variation; Risk factor; Risk assessment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002972455,0.0006817413,0.0004274378,0.001483927,0.0002811028,0.0006661869,0.0004662368,0.0003704175,0.002455387],"category_scores_gemma":[0.00761131,0.0001434247,0.000793562,0.0008507217,0.0003888347,0.0002793896,0.0007594755,0.0005480301,0.0003091027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049287,"about_ca_system_score_gemma":0.0002964171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003782396,"about_ca_topic_score_gemma":0.005203112,"domain_scores_codex":[0.9990222,0.0003987355,0.00005952732,0.0003205724,0.0001446819,0.00005422872],"domain_scores_gemma":[0.9967059,0.002071774,0.0005037647,0.0003557898,0.0002334506,0.0001292028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007544846,0.00008906476,0.9138565,0.00005001425,0.001116208,0.0002581162,0.0001782192,0.009837028,0.004023452,0.0009090356,0.0009025754,0.06802537],"study_design_scores_gemma":[0.0001307209,0.0005310234,0.8798329,0.00003168942,0.0006505252,0.001142535,0.0001423262,0.1117532,0.002101241,0.00239246,0.001234,0.00005726131],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981321,0.00009548459,0.01690459,0.00006926231,0.00001243996,0.00002688468,0.0005326015,0.0002141612,0.0008236057],"genre_scores_gemma":[0.990371,0.00003637552,0.008686656,0.00001620635,0.00001148506,0.00001511617,0.0006251,0.00002926199,0.0002088989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003782396,"threshold_uncertainty_score":0.01572001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01724013060637161,"score_gpt":0.276741167589233,"score_spread":0.2595010369828614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}