{"id":"W7117248510","doi":"10.1002/alz70859_096394","title":"Development and Characterization of Small Molecule Chemical Probes for Alzheimer's Disease‐associated Human RNA Helicases","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Small molecule; Drug discovery; Context (archaeology); In vitro; MDA5; Ligand (biochemistry); RNA; Chemical biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000579678,0.0005181516,0.000423946,0.0003826458,0.0001682587,0.0003269173,0.0003514776,0.0004970173,0.001164578],"category_scores_gemma":[0.0004881833,0.0001920373,0.0003798099,0.0002731492,0.0001878821,0.0002662001,0.0001979023,0.0004364228,0.000638633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004800517,"about_ca_system_score_gemma":0.0004098623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002813511,"about_ca_topic_score_gemma":0.0007287324,"domain_scores_codex":[0.9997182,0.00005085475,0.00002082406,0.00005270621,0.0001183166,0.00003902952],"domain_scores_gemma":[0.9997237,0.0000726123,0.00004807543,0.000023249,0.00008572203,0.00004665598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004982762,0.00005989661,0.000203541,0.00009491388,0.000009467173,0.0000428001,0.00001417469,0.0005258787,0.9935136,0.00009683704,0.00006753059,0.005321547],"study_design_scores_gemma":[0.00002058709,0.0006620716,0.0005183545,0.000007238557,0.00001294628,0.0001404386,0.00001166289,0.001549746,0.9944059,0.00003674655,0.002626057,0.00000830508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.884212,0.008244222,0.09820569,0.0004396691,0.00007465292,0.001173593,0.002390278,0.0005455439,0.004714346],"genre_scores_gemma":[0.8709657,0.005500972,0.1126094,0.0003272093,0.00004317941,0.0008965248,0.003626432,0.00008516794,0.005945374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164578,"threshold_uncertainty_score":0.003895938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02302074269694323,"score_gpt":0.2649884689737791,"score_spread":0.2419677262768359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}