{"id":"W7117249539","doi":"10.1002/alz70857_096615","title":"Different Patterns of Propagation of Tau Tangle Pathology in Typical Alzheimer's Disease Determine Clinical Sub‐Phenotypes","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Disease; Deposition (geology); Tangle; Tau pathology; Neurofibrillary tangle; Tauopathy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003711472,0.0002850618,0.0002138568,0.001111532,0.0002228194,0.0004325756,0.0001789078,0.0003171077,0.001326518],"category_scores_gemma":[0.00089944,0.000151375,0.0002062509,0.0004114916,0.0003293668,0.0003093545,0.0002604321,0.0002164714,0.0002591627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001432917,"about_ca_system_score_gemma":0.0001075738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096576,"about_ca_topic_score_gemma":0.002031714,"domain_scores_codex":[0.999893,0.0000160464,0.00001582898,0.0000383698,0.00001869766,0.00001802113],"domain_scores_gemma":[0.9995351,0.0001009277,0.0001941426,0.00004765493,0.00006508807,0.00005725161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001144863,0.00004989815,0.9178411,0.00005121281,0.0001415171,0.001105452,0.0006304542,0.0003377529,0.06314781,0.000102822,0.000159591,0.01528744],"study_design_scores_gemma":[0.000006450885,0.0001169581,0.9954318,0.000004350218,0.00002936709,0.002053973,0.0001202043,0.0002403383,0.001770439,0.0001306921,0.00009151187,0.000003913656],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992017,0.0001125798,0.0003020419,0.000005545947,7.48872e-7,0.000005219901,0.0000877487,0.00001359057,0.000270907],"genre_scores_gemma":[0.9991842,0.00006885462,0.0004104894,0.000004504016,0.00000166947,0.000005396126,0.0001968403,0.000005551066,0.0001224032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001326518,"threshold_uncertainty_score":0.004437685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03527786160179842,"score_gpt":0.3489790223961955,"score_spread":0.3137011607943971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}