{"id":"W7117250300","doi":"10.1002/alz70859_098668","title":"Combining humanized mice, neurochemical, imaging, and cognitive biomarkers for drug discovery in mice.","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Drug discovery; Drug; Synucleinopathies; Drug development; Biomarker discovery; Cognition; Pipeline (software); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003969356,0.002611636,0.001099162,0.003078409,0.0005606576,0.001557251,0.002264353,0.002551493,0.005305829],"category_scores_gemma":[0.0006850819,0.001422761,0.001732163,0.0009699889,0.00153829,0.001577647,0.00130816,0.003475911,0.002444091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001250608,"about_ca_system_score_gemma":0.001286239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008794239,"about_ca_topic_score_gemma":0.002155132,"domain_scores_codex":[0.9984381,0.0003247996,0.0001864417,0.0003783863,0.0004490857,0.0002233488],"domain_scores_gemma":[0.9985403,0.0001934268,0.0004931126,0.0003047521,0.0001674659,0.0003009297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001097086,0.0009401582,0.0006758145,0.0004317592,0.0001570949,0.0002527703,0.0001014943,0.0008279462,0.9791136,0.002660911,0.002243735,0.01149762],"study_design_scores_gemma":[0.000830036,0.003784533,0.00286648,0.0002040352,0.0003202964,0.001922958,0.00005876583,0.004954642,0.9324875,0.001338284,0.05116335,0.00006919989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3011939,0.01209757,0.6277731,0.005323973,0.001494391,0.006020353,0.01985572,0.01325953,0.01298143],"genre_scores_gemma":[0.4156,0.0116955,0.5043079,0.002544173,0.0003834346,0.01195979,0.01937303,0.00194965,0.03218648],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005305829,"threshold_uncertainty_score":0.02099222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452379466023412,"score_gpt":0.284294231203443,"score_spread":0.2697704365432089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}