{"id":"W7117255132","doi":"10.1002/alz70859_097989","title":"Multiple‐Dose Results from an Ongoing Phase 1 Study of Mivelsiran, an Investigational RNA Interference Therapeutic Targeting Amyloid‐Beta Precursor Protein for Alzheimer’s Disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"RNA interference; Disease; Amyloid precursor protein; Interference (communication); RNA; Clinical disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002201422,0.001134289,0.00175608,0.0003005932,0.000402225,0.0007113123,0.000655111,0.0007773116,0.002937518],"category_scores_gemma":[0.001105781,0.0004032131,0.001345882,0.0002622578,0.0005884562,0.0006380961,0.0003017083,0.002407662,0.0006456588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005631198,"about_ca_system_score_gemma":0.001016921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000523479,"about_ca_topic_score_gemma":0.001272856,"domain_scores_codex":[0.9993657,0.0002839584,0.00004925032,0.0001025644,0.00009997411,0.00009863332],"domain_scores_gemma":[0.9988844,0.0002211329,0.0002851532,0.0001329747,0.0001248027,0.0003514845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7176748,0.07289073,0.01080334,0.000589662,0.002900269,0.0002705847,0.0002801785,0.00218993,0.1118402,0.0002312241,0.004387321,0.07594185],"study_design_scores_gemma":[0.2974588,0.6502842,0.03052282,0.00002581663,0.001256606,0.00041222,0.00006135523,0.001163814,0.01461722,0.0002584039,0.003890192,0.00004863107],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942561,0.000918521,0.0008107443,0.0001849232,0.00006186022,0.001208432,0.001445851,0.00005760428,0.001056039],"genre_scores_gemma":[0.9881429,0.0007946271,0.002343197,0.0004477196,0.00009083442,0.002105398,0.004147356,0.00003083582,0.00189715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002937518,"threshold_uncertainty_score":0.0116424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0481298563576287,"score_gpt":0.3250878462842468,"score_spread":0.2769579899266181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}