{"id":"W7117293899","doi":"10.3390/biomedicines14010049","title":"HER2-Low Breast Cancer at the Interface of Pathology and Technology: Toward Precision Management","year":2025,"lang":"en","type":"article","venue":"Biomedicines","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; Queen's University","funders":"","keywords":"Liquid biopsy; Breast cancer; Biopsy; Histopathology; Narrative review; Standardization; Precision medicine; Targeted therapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01521374,0.000842511,0.001560648,0.003768114,0.0008240168,0.006976711,0.001717722,0.002742553,0.001840297],"category_scores_gemma":[0.01940133,0.0004230066,0.001096685,0.002275093,0.004411638,0.006999091,0.00382288,0.004306183,0.001006949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003219231,"about_ca_system_score_gemma":0.006694014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00144568,"about_ca_topic_score_gemma":0.001548014,"domain_scores_codex":[0.9935268,0.002896527,0.0006033481,0.0006135583,0.00212143,0.0002383508],"domain_scores_gemma":[0.9763564,0.01630368,0.002336326,0.0009008827,0.003668879,0.0004338773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001446571,0.00008753448,0.004932214,0.02602903,0.0004106983,0.0007310596,0.001405902,0.002019503,0.004970712,0.1062174,0.040235,0.8128163],"study_design_scores_gemma":[0.00003402927,0.0002969092,0.003790121,0.03904014,0.0007343292,0.002806091,0.00323939,0.002589697,0.00655528,0.1771828,0.7635565,0.000174644],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.002090764,0.9159468,0.0206195,0.05495316,0.00123071,0.00004382714,0.0001203266,0.0001278939,0.004867118],"genre_scores_gemma":[0.05567694,0.8859599,0.03638488,0.01653358,0.003684502,0.0001295213,0.0002109576,0.00005986682,0.001359833],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01521374,"threshold_uncertainty_score":0.08045894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02004963635190948,"score_gpt":0.3952219347587839,"score_spread":0.3751722984068744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}