{"id":"W7117294376","doi":"10.1002/adfm.202529443","title":"Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models","year":2025,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Université de Fribourg; Universitair Medisch Centrum Groningen; ZonMw; Rijksuniversiteit Groningen; European Commission; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Glioma; RNA; Glioblastoma; Zebrafish; PLGA; Cytokine; Tumor microenvironment; Immunotherapy; Spheroid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645494,0.0002065724,0.0002310002,0.0001195031,0.0001135841,0.00005242644,0.0001490494,0.0001509256,0.00004976791],"category_scores_gemma":[0.00006354161,0.0002110862,0.00008466994,0.00009778969,0.00003749476,0.00003749618,0.00008138955,0.0000506668,0.00002096607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004789665,"about_ca_system_score_gemma":0.000111579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001787587,"about_ca_topic_score_gemma":0.0000350472,"domain_scores_codex":[0.9986891,0.00004922181,0.0003695985,0.0004421883,0.0001069817,0.0003428801],"domain_scores_gemma":[0.9994455,0.00003692141,0.00009579601,0.0002523597,0.0001180004,0.00005142644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002145494,0.0000762261,0.00006011796,0.00004765112,0.00007173079,0.000001844536,0.00002662562,0.0004616575,0.9914919,0.0005999766,0.0007103928,0.004306403],"study_design_scores_gemma":[0.001169505,0.0003279059,0.0006441836,0.000052232,0.00002410209,0.000006070883,0.00007852153,0.0001062207,0.9915953,0.0022928,0.003488786,0.0002143671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917893,0.001234175,0.005342957,0.000144313,0.0007259442,0.0003174531,0.0001276856,0.00003721842,0.0002809891],"genre_scores_gemma":[0.996576,0.0001639269,0.00129242,0.0008283819,0.0002023192,0.0002978354,0.00009511254,0.0000230636,0.0005209395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004786735,"threshold_uncertainty_score":0.8607844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607087242612345,"score_gpt":0.2632153276797136,"score_spread":0.2471444552535901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}