{"id":"W7117294376","doi":"10.1002/adfm.202529443","title":"Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models","year":2025,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Université de Fribourg; Universitair Medisch Centrum Groningen; ZonMw; Rijksuniversiteit Groningen; European Commission; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Glioma; RNA; Glioblastoma; Zebrafish; PLGA; Cytokine; Tumor microenvironment; Immunotherapy; Spheroid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500793,0.000395703,0.0001735743,0.0001993927,0.00009093593,0.0001769733,0.0001958752,0.000277152,0.0004892789],"category_scores_gemma":[0.00005061966,0.0001182848,0.0001685466,0.00007997108,0.0001501282,0.000153762,0.0001252141,0.0003481378,0.0001745988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485894,"about_ca_system_score_gemma":0.0001771725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105764,"about_ca_topic_score_gemma":0.001180511,"domain_scores_codex":[0.9999173,0.00001464886,0.000005540754,0.00001878534,0.00002390805,0.0000198227],"domain_scores_gemma":[0.9999684,0.000004501859,0.00001151481,0.000003227506,0.000006068906,0.000006223976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004476157,0.00003101782,0.00002130474,0.00002579893,0.00000214312,0.00001638129,0.000008222644,0.0001483099,0.9986939,0.00007014556,0.00003732992,0.0009006855],"study_design_scores_gemma":[0.000007968923,0.0002225587,0.0001660216,0.00000251643,0.000006767524,0.00002505694,0.000004372852,0.001613295,0.9971569,0.0000139353,0.0007786261,0.000002035944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715944,0.001575083,0.0241123,0.0001525669,0.00007241832,0.0001542829,0.0003300562,0.00035906,0.001649859],"genre_scores_gemma":[0.9836668,0.0008830856,0.01251481,0.00003689897,0.00000934489,0.0001464692,0.0001838509,0.00003124028,0.00252743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105764,"threshold_uncertainty_score":0.002102911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607087242612345,"score_gpt":0.2632153276797136,"score_spread":0.2471444552535901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}