{"id":"W7117296061","doi":"10.64898/2025.12.24.696400","title":"HIV Nef amplifies mechanical heterogeneity to promote immune evasion","year":2025,"lang":"en","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic; University of Toronto","funders":"","keywords":"Cytotoxic T cell; Immune system; Cytoskeleton; Phenotype; Evasion (ethics); Immunity; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001069657,0.0001388133,0.0001151352,0.0001272856,0.0001100337,0.0003345658,0.0001089369,0.0002144636,0.00135604],"category_scores_gemma":[0.0001297886,0.00009099369,0.00008512875,0.00003533367,0.0002042873,0.0001557719,0.0002514163,0.0003663024,0.0001777399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002097479,"about_ca_system_score_gemma":0.00007337495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001467198,"about_ca_topic_score_gemma":0.0002686444,"domain_scores_codex":[0.9999158,0.00001515038,0.000003590044,0.000009562345,0.00002551394,0.00003034025],"domain_scores_gemma":[0.9999138,0.00002082587,0.00002455667,0.00001010643,0.000007739975,0.00002294012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003493152,0.00002237204,0.0002382992,0.00001108821,0.000002686716,0.00003870164,0.000005115635,0.00008784917,0.9981853,0.000187848,0.00006414073,0.001121445],"study_design_scores_gemma":[0.00004417136,0.0004105881,0.01239611,0.00001327476,0.00001043444,0.0005124248,0.00007326561,0.005045441,0.9772668,0.0004544935,0.003766079,0.000006851026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963865,0.0005360427,0.001317586,0.0001671331,0.00001671064,0.00001063907,0.00003432772,0.00002854695,0.001502465],"genre_scores_gemma":[0.9990583,0.0000896118,0.0002982455,0.00005234438,0.000007490049,0.000004853691,0.00001749072,0.00000284808,0.0004688036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135604,"threshold_uncertainty_score":0.00453639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330138210405859,"score_gpt":0.2475822367458022,"score_spread":0.2342808546417436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}