{"id":"W7117298434","doi":"10.64898/2025.12.25.695625","title":"Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis","year":2025,"lang":"en","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Center for Advancing Translational Sciences","keywords":"Oncostatin M; Idiopathic pulmonary fibrosis; Fibrosis; Pulmonary fibrosis; Lung; Inflammation; Myofibroblast; Pathogenesis; Interleukin 6","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275522,0.000242583,0.000324182,0.0001512332,0.00009660721,0.0002643593,0.0001453051,0.000229297,0.00139984],"category_scores_gemma":[0.00007775357,0.00006593962,0.0002720866,0.0001008296,0.0001655939,0.0001673577,0.0001635846,0.0009649612,0.0002708376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001325827,"about_ca_system_score_gemma":0.0002152402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001880492,"about_ca_topic_score_gemma":0.0005539657,"domain_scores_codex":[0.9998927,0.00002074436,0.00001279904,0.00001079241,0.00002678403,0.00003621633],"domain_scores_gemma":[0.999936,0.00001038242,0.00001494035,0.000005491361,0.000005986126,0.00002726814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007044095,0.0001919937,0.0004342656,0.00008210894,0.00001865747,0.00004490651,0.00000926231,0.00009300897,0.9928204,0.0000646972,0.0001373717,0.005398836],"study_design_scores_gemma":[0.0002426163,0.005403655,0.007340883,0.00001381285,0.0001008763,0.0005034599,0.00004081725,0.001389496,0.9807374,0.0000484235,0.004172054,0.000006489473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994504,0.002410223,0.001504337,0.0001923721,0.00008121115,0.00003452307,0.0002528443,0.00007827344,0.0009422815],"genre_scores_gemma":[0.9965065,0.0009387161,0.00131047,0.00007326393,0.00002779078,0.00003041417,0.0002645552,0.000004872958,0.0008433593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139984,"threshold_uncertainty_score":0.004682958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005727327402535576,"score_gpt":0.2139395707046567,"score_spread":0.2082122433021211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}