{"id":"W7117298964","doi":"10.1016/j.iotech.2025.101461","title":"262P EGFR mutations (EGFR+) or ALK rearrangements (ALK+) in the BR31 trial of adjuvant durvalumab (D) v placebo (P)","year":2025,"lang":"en","type":"article","venue":"Immuno-Oncology Technology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Cancer Society; Dalhousie University; University of Ottawa","funders":"","keywords":"Durvalumab; Placebo; Adjuvant; Mutation; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004434023,0.0002222339,0.0006725526,0.0008481463,0.0001651732,0.000009509838,0.0004070332,0.0004916962,0.0002302731],"category_scores_gemma":[0.0006489678,0.0001506634,0.0001215931,0.001288305,0.0005704977,0.00006714294,0.0001164721,0.0004446645,0.00003594239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006202758,"about_ca_system_score_gemma":0.001132924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003597279,"about_ca_topic_score_gemma":0.0008505776,"domain_scores_codex":[0.9981196,0.000191279,0.0007219705,0.0003707593,0.0001961415,0.0004002683],"domain_scores_gemma":[0.9982532,0.0005526741,0.0002414773,0.0007608936,0.0001625459,0.00002920036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1296142,0.01513259,0.02178989,0.0004641286,0.006047468,0.001825454,0.01256714,0.00006977289,0.03764157,0.04771216,0.0333566,0.693779],"study_design_scores_gemma":[0.3642858,0.01265736,0.01544963,0.0005170032,0.002866842,0.0005378767,0.02393909,0.0001035293,0.0073483,0.009187351,0.5626138,0.000493369],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8606147,0.002662805,0.0003075606,0.05210539,0.002051724,0.005007078,0.00006607618,0.0002844795,0.07690024],"genre_scores_gemma":[0.9926136,0.000381049,0.001600665,0.0008031616,0.00005316673,0.001367572,0.0000981218,0.00002197054,0.003060733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6932856,"threshold_uncertainty_score":0.6143876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01786102216622019,"score_gpt":0.3937564791857949,"score_spread":0.3758954570195747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}