{"id":"W7117304503","doi":"10.1002/alz70859_103550","title":"Focused Ultrasound Enhances Targeted Gene Delivery of Intravenous AAV to the Brain","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ontario Brain Institute; Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto","funders":"","keywords":"Focused ultrasound; Gene delivery; Genetic enhancement; Gene; Ultrasound","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002536207,0.0004154409,0.0002448,0.0004662743,0.00008654642,0.0002761945,0.0002637013,0.0003338337,0.001542533],"category_scores_gemma":[0.0002233987,0.0001515447,0.0002331905,0.0001125231,0.0003185791,0.0003308756,0.0002623343,0.0003673217,0.0002803737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003822157,"about_ca_system_score_gemma":0.0002626337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102757,"about_ca_topic_score_gemma":0.001173338,"domain_scores_codex":[0.9998708,0.00002061941,0.000007172909,0.00003588562,0.00003040098,0.00003517815],"domain_scores_gemma":[0.9998674,0.0000424978,0.00003244871,0.000007074663,0.00002499344,0.00002554818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005858625,0.00001896903,0.00007393611,0.00004062682,0.000002869481,0.00004290638,0.00002069454,0.00006847872,0.9966297,0.00009428369,0.00004141811,0.00290756],"study_design_scores_gemma":[0.00001956089,0.001108138,0.002758538,0.00002478347,0.00003459811,0.0004285712,0.00002935494,0.001262704,0.992269,0.0001044807,0.00195455,0.000005977199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960514,0.004760755,0.02947415,0.0002038728,0.0000808607,0.0001129332,0.0001377845,0.0004029808,0.004312583],"genre_scores_gemma":[0.9754336,0.002725854,0.0172775,0.0001065683,0.00006553392,0.00005807462,0.0001410385,0.00005729095,0.004134448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001542533,"threshold_uncertainty_score":0.005160332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00935741395513051,"score_gpt":0.2209047997010665,"score_spread":0.211547385745936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}