{"id":"W7117306355","doi":"10.14336/ad.2025.1391","title":"Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance","year":2025,"lang":"en","type":"article","venue":"Aging and Disease","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"","keywords":"Hormone replacement therapy (female-to-male); Narrative review; Menopause; Clinical significance; Hypoestrogenism; Premature Menopause; Endocrine system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004923868,0.0005633945,0.00146622,0.001257876,0.0004306505,0.002243597,0.001438971,0.003132119,0.003937978],"category_scores_gemma":[0.01268443,0.0002678013,0.001096003,0.000688001,0.000895326,0.001756289,0.001175103,0.005885336,0.001817101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001332028,"about_ca_system_score_gemma":0.004548555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003248362,"about_ca_topic_score_gemma":0.009246493,"domain_scores_codex":[0.9983682,0.0006800505,0.0003359391,0.0001751403,0.0003521653,0.00008847775],"domain_scores_gemma":[0.9932529,0.00408202,0.0004177109,0.0001912576,0.001746042,0.0003100248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003566433,0.0002047375,0.0007262962,0.01697435,0.0001762228,0.0002853039,0.0003492481,0.0006118349,0.0009195303,0.01877898,0.1052264,0.8553904],"study_design_scores_gemma":[0.000152792,0.0002777643,0.001245937,0.03640517,0.000270495,0.0005496306,0.0002383067,0.0002719753,0.0003495317,0.01262086,0.9475773,0.00004020276],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008490853,0.9199923,0.002340836,0.06402757,0.003605157,0.0001313483,0.0002534048,0.00008477677,0.008715387],"genre_scores_gemma":[0.009519434,0.948375,0.008523474,0.02572859,0.004714115,0.0002548942,0.0002985983,0.00003101505,0.002554736],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004923868,"threshold_uncertainty_score":0.0260402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04798879332195136,"score_gpt":0.3903860364550856,"score_spread":0.3423972431331342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}