{"id":"W7117307252","doi":"10.1002/alz70859_101851","title":"Efficacy and safety of MT104, a dietary supplement based on <i>Cuscuta</i> seeds and heat‐killed probiotics, on cognitive function in patients with mild cognitive impairment: A 12‐week, multicenter, randomized, double‐blind, placebo‐controlled clinical trial","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cognition; Dietary supplement; Clinical trial; Randomized controlled trial; Alternative medicine; Effects of sleep deprivation on cognitive performance","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007406478,0.001269534,0.00279932,0.0004016501,0.0004855521,0.0006713172,0.0007234387,0.001904454,0.003074874],"category_scores_gemma":[0.0007764369,0.0005417084,0.001254121,0.0003281926,0.0006924358,0.0006149544,0.0003155386,0.001649131,0.0004474588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003717552,"about_ca_system_score_gemma":0.000662419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006572902,"about_ca_topic_score_gemma":0.001131973,"domain_scores_codex":[0.9997155,0.0001103174,0.00003123384,0.00006693923,0.00003191682,0.00004407862],"domain_scores_gemma":[0.9995822,0.00007139685,0.0001217684,0.00002694971,0.00005024029,0.0001473761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9584044,0.01316387,0.0005144745,0.0009500376,0.001003201,0.00003663623,0.00004150118,0.000118493,0.01002696,0.00003328185,0.0003260529,0.01538109],"study_design_scores_gemma":[0.6989517,0.2922402,0.004454675,0.00007662846,0.001391535,0.0000399592,0.0000340295,0.000383528,0.001808547,0.00005116702,0.0005441597,0.00002385911],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927956,0.00459387,0.0002443044,0.000236893,0.0002322608,0.00112041,0.0002394186,0.00005075405,0.0004865816],"genre_scores_gemma":[0.9929462,0.00250123,0.0007287332,0.0005154558,0.0002756251,0.001623626,0.0003353244,0.000009194128,0.001064659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003074874,"threshold_uncertainty_score":0.01028651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208118874466988,"score_gpt":0.3004089428155527,"score_spread":0.2795970553688539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}