{"id":"W7117307984","doi":"10.1016/j.celrep.2025.116775","title":"IgG2c subclass dominance drives fatal lupus-like nephritis via FcγR and complement activation","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission; National Key Research and Development Program of China; Chinese Academy of Sciences; National Natural Science Foundation of China; Natural Science Foundation of Shanghai; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College; Science and Technology Commission of Shanghai Municipality","keywords":"Lupus nephritis; Subclass; Nephritis; Immune system; Complement system; Dominance (genetics); Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002828448,0.0004966654,0.0003169813,0.0004888118,0.0001998429,0.0004809895,0.0002581764,0.000509945,0.001452032],"category_scores_gemma":[0.0001618892,0.0002046924,0.0002917726,0.0001685221,0.0004160556,0.0001997815,0.0003459307,0.0009408846,0.0004149594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004873198,"about_ca_system_score_gemma":0.0003731048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001014745,"about_ca_topic_score_gemma":0.0021912,"domain_scores_codex":[0.9995498,0.00008480705,0.00003929207,0.00008858542,0.0001146377,0.0001227899],"domain_scores_gemma":[0.999703,0.00003564625,0.00009716555,0.00003141477,0.00001620742,0.0001165385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001440834,0.00006561833,0.000531885,0.00003215656,0.000007776685,0.0002143154,0.00002841747,0.0001033833,0.997637,0.0003063235,0.00008719952,0.0008417123],"study_design_scores_gemma":[0.0001518937,0.001155932,0.0126028,0.00003629022,0.00005718647,0.003347198,0.0001446104,0.00324103,0.9745354,0.000382661,0.004327477,0.00001760241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951079,0.0006343056,0.001854777,0.0001227735,0.00002072813,0.00003159454,0.0003221512,0.0001531784,0.001752518],"genre_scores_gemma":[0.9960724,0.0002717,0.001021393,0.00007169309,0.00001023168,0.00002576099,0.0002159438,0.00003055438,0.00228046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452032,"threshold_uncertainty_score":0.00485754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422216890186477,"score_gpt":0.2866665493157486,"score_spread":0.2724443804138839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}