{"id":"W7117310866","doi":"10.1002/alz.71033","title":"PAK1 inhibitor NVS‐PAK1‐1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Aging; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Jean Perkins Foundation; National Institutes of Health; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Pfizer; Genentech; University of Pittsburgh; Applebaum Foundation; McGill University; Bayer; Pharmaceutical Research and Manufacturers of America Foundation","keywords":"Dendritic spine; Cofilin; Hippocampal formation; Actin cytoskeleton; PAK1; Kinase; ROCK2; Actin; CDC42; SPINE (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417194,0.0005273726,0.0004270131,0.000392296,0.0002546104,0.0002858889,0.0003286654,0.0005268616,0.001910824],"category_scores_gemma":[0.0000715587,0.0001886004,0.000403177,0.0001725387,0.0002849738,0.000327529,0.0001219026,0.001218961,0.0005966071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003532028,"about_ca_system_score_gemma":0.0003331555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001106678,"about_ca_topic_score_gemma":0.001835043,"domain_scores_codex":[0.9998645,0.000008343855,0.0000144315,0.0000345331,0.00003298117,0.00004526314],"domain_scores_gemma":[0.9999201,0.00000538419,0.00002526598,0.000007359251,0.00001215507,0.00002971835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006193621,0.0002355251,0.0002233994,0.00009877454,0.00001644502,0.00006329498,0.00003151198,0.0000677647,0.9961945,0.0001301366,0.0002591745,0.002060201],"study_design_scores_gemma":[0.00009399054,0.002106383,0.007042061,0.00003140348,0.00005597635,0.0003163881,0.00007369132,0.0007393629,0.9865242,0.0001102429,0.00289617,0.00001010331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914043,0.002281519,0.001584892,0.0002737433,0.0001077153,0.00005587748,0.002138662,0.0002170719,0.001936294],"genre_scores_gemma":[0.9810159,0.002881715,0.002828228,0.0001619936,0.00003851441,0.0002292641,0.002553678,0.00005085958,0.01023996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001910824,"threshold_uncertainty_score":0.00639236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02791185641657308,"score_gpt":0.3079490005625194,"score_spread":0.2800371441459463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}