{"id":"W7117312136","doi":"10.1021/acschemneuro.5c00688","title":"Cardiolipin-Based Nanoparticles Inhibit α-Synuclein Fibrilization","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Circular dichroism; Synucleinopathies; Nanoparticle; Protein aggregation; Intracellular; Monomer; Transmission electron microscopy; Cell; Cardiolipin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005732591,0.0001171443,0.0001689055,0.00006676174,0.00008239506,0.00003162546,0.0001028867,0.00003916934,0.00001036054],"category_scores_gemma":[0.0002824703,0.0001007103,0.00007058873,0.0005205632,0.0001236836,0.00006892399,0.00005620686,0.00006666651,0.00001995895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005206882,"about_ca_system_score_gemma":0.0001249683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005616906,"about_ca_topic_score_gemma":1.677564e-7,"domain_scores_codex":[0.9989444,0.00001910651,0.0001485115,0.0003958367,0.0002504042,0.0002417307],"domain_scores_gemma":[0.9994657,0.00003518352,0.00003029715,0.0002711205,0.00004691549,0.0001507799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005599854,0.0001432345,0.00552079,0.00002600839,0.000003573618,0.00003962051,0.000004314655,0.00002047314,0.9919907,0.0004024926,0.000420264,0.001372535],"study_design_scores_gemma":[0.0008550627,0.00005537409,0.01193191,0.00006217201,0.00005444181,0.000008020527,0.000003213237,0.002253964,0.9762012,0.0002417072,0.008254179,0.0000787856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996853,0.00007317463,0.0004140388,0.001052203,0.0001556285,0.0001920564,0.000008023628,0.0001017221,0.00115018],"genre_scores_gemma":[0.9956583,0.000009244889,0.0002753254,0.003770831,0.00002305762,0.00001992702,0.000008030005,0.000008537879,0.0002267427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01578953,"threshold_uncertainty_score":0.4106845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01647991501382749,"score_gpt":0.272837375109146,"score_spread":0.2563574600953185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}