{"id":"W7117312844","doi":"10.1002/alz70859_103159","title":"PRECISE‐AD, A Phase 1b, Double‐Blind, Placebo‐Controlled, Multiple Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of PMN310 in Patients with Early Alzheimer's Disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Amorfix (Canada)","funders":"","keywords":"Monoclonal antibody; Disease; Clinical trial; Antibody; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002271669,0.002722483,0.002128976,0.0006773762,0.0005985558,0.0009788815,0.001088011,0.001980591,0.004722646],"category_scores_gemma":[0.001016035,0.0008397563,0.0008672911,0.0004232236,0.001352772,0.001358506,0.0003288763,0.003272527,0.0008659163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000701544,"about_ca_system_score_gemma":0.001957193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005954621,"about_ca_topic_score_gemma":0.001635103,"domain_scores_codex":[0.9995089,0.0001930188,0.00003270006,0.0001170456,0.00007044651,0.00007795339],"domain_scores_gemma":[0.9992461,0.0001101714,0.0002072362,0.00006693672,0.0000741955,0.0002953302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8577288,0.0642169,0.001573833,0.0008734859,0.0006768004,0.0001148867,0.0001610247,0.0007771056,0.03856337,0.0003149246,0.002568304,0.0324305],"study_design_scores_gemma":[0.7308553,0.2617023,0.002934808,0.00001936333,0.0002203662,0.00007925811,0.00002086185,0.0003509186,0.002271275,0.0001559514,0.001367442,0.00002215888],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845406,0.003245088,0.001066424,0.0003739746,0.0002033989,0.006293192,0.001699717,0.0002473898,0.002330267],"genre_scores_gemma":[0.981222,0.001984471,0.003194167,0.001142625,0.0002771708,0.00574733,0.002104813,0.00004041588,0.004287009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004722646,"threshold_uncertainty_score":0.01579887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02545737777462257,"score_gpt":0.3348946787011707,"score_spread":0.3094373009265481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}