{"id":"W7117316366","doi":"10.1016/j.iotech.2025.101405","title":"408P Calpain as a novel therapeutic target in breast cancer","year":2025,"lang":"en","type":"article","venue":"Immuno-Oncology Technology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Queen's University","funders":"","keywords":"Breast cancer; Calpain; Cancer; Human breast; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002795139,0.0001962472,0.000266129,0.0004385668,0.0001000311,0.000009591406,0.000289126,0.0009521501,0.0001713166],"category_scores_gemma":[0.00007063807,0.0001889134,0.00008282052,0.0006017752,0.0003459411,0.000004526837,0.0001879707,0.0002898111,0.0000199771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835422,"about_ca_system_score_gemma":0.0004844859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001518297,"about_ca_topic_score_gemma":0.000223255,"domain_scores_codex":[0.9987046,0.00008935835,0.0003241815,0.0004505518,0.00006803157,0.0003632421],"domain_scores_gemma":[0.9993068,0.00002356583,0.00009920566,0.0004354552,0.0001049517,0.00003000318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004227845,0.0002962803,0.0167539,0.00001494018,0.0001392629,0.000007839653,0.00002402439,0.0001126563,0.9296818,0.006276868,0.001860941,0.04440865],"study_design_scores_gemma":[0.00498143,0.0005533932,0.03116335,0.00007740186,0.00005755819,0.0003438161,0.0005346194,0.0006515048,0.17064,0.009165324,0.7813051,0.0005264974],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9122859,0.01006792,0.01657928,0.05062465,0.001859914,0.001127203,0.00005036803,0.0002570157,0.007147746],"genre_scores_gemma":[0.992755,0.0003897818,0.0005292237,0.002724645,0.00007673888,0.0003873432,0.00005190906,0.00002126726,0.003064068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7794442,"threshold_uncertainty_score":0.7703666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004559655176082028,"score_gpt":0.2819368003166113,"score_spread":0.2773771451405293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}