{"id":"W7117320832","doi":"10.1002/alz70856_103517","title":"Translational cognitive biomarkers for preclinical drug testing in neurodegenerative diseases","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Robarts Clinical Trials; Montreal Neurological Institute and Hospital; Douglas Mental Health University Institute; McGill University; Western University","funders":"","keywords":"Drug; Cognition; Preclinical testing; Clinical trial; Drug trial; Drug response; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008363621,0.002108408,0.001405916,0.001650143,0.000456518,0.001881085,0.001356477,0.001504944,0.005835149],"category_scores_gemma":[0.006103521,0.0004006672,0.001022843,0.0009817895,0.001117035,0.001684612,0.000985006,0.002351408,0.001368648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001341515,"about_ca_system_score_gemma":0.001967179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000788911,"about_ca_topic_score_gemma":0.001031543,"domain_scores_codex":[0.9976175,0.000976727,0.0001632929,0.0002617915,0.0008097051,0.0001709055],"domain_scores_gemma":[0.9941229,0.001277199,0.001704097,0.0005368163,0.001915459,0.0004434698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005219206,0.004755682,0.03267145,0.002285806,0.0005753838,0.0004036476,0.0001979484,0.004727833,0.6736571,0.006042756,0.009388154,0.2600751],"study_design_scores_gemma":[0.001371803,0.06693146,0.07671153,0.001157521,0.001734722,0.002705925,0.0003778062,0.02218111,0.7582813,0.01271043,0.05558417,0.000252195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6264952,0.04414546,0.2541995,0.007124505,0.002603789,0.009794973,0.01376164,0.006721991,0.03515295],"genre_scores_gemma":[0.8165741,0.01229403,0.1491539,0.003397835,0.0007057062,0.004980395,0.006686334,0.0002401576,0.005967532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008363621,"threshold_uncertainty_score":0.04423159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06763989465710611,"score_gpt":0.3775702959987182,"score_spread":0.309930401341612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}