{"id":"W7117321010","doi":"10.1021/acsinfecdis.5c00843","title":"Negamycin: Nature’s Forgotten Antibiotic","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Formulary; Drug discovery; Antibiotics; Natural product; Drug; Broad spectrum; Mode of action; Drug development","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007063649,0.0004520684,0.0005432514,0.0006842036,0.0005557656,0.001693944,0.0005449462,0.001742467,0.003788051],"category_scores_gemma":[0.001212219,0.0002254086,0.0002859601,0.0006214778,0.001805612,0.002526894,0.001035169,0.003240179,0.004412059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001254933,"about_ca_system_score_gemma":0.001175545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007149169,"about_ca_topic_score_gemma":0.001654902,"domain_scores_codex":[0.9994174,0.0001216091,0.00004290421,0.0001108681,0.0002561933,0.00005106379],"domain_scores_gemma":[0.9994839,0.0002083339,0.00005870117,0.00003949046,0.0001189436,0.00009055661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002569087,0.00008948724,0.0006607244,0.0041491,0.00005673148,0.0007192964,0.0004447804,0.0004763142,0.0271925,0.06580658,0.2437631,0.6563845],"study_design_scores_gemma":[0.000006357831,0.00005332503,0.0001369707,0.0002224427,0.000005923743,0.0003952631,0.0000376552,0.00003311051,0.001779844,0.00426763,0.9930519,0.000009597585],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002119221,0.9384841,0.002104688,0.02245545,0.01308354,0.00001783422,0.000188324,0.0001364832,0.02141046],"genre_scores_gemma":[0.02342151,0.9144656,0.002126462,0.02648726,0.005461682,0.00004921404,0.0003018943,0.00007733822,0.02760911],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003788051,"threshold_uncertainty_score":0.01267231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003460437251339371,"score_gpt":0.2430321251192382,"score_spread":0.2395716878678988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}