{"id":"W7117321010","doi":"10.1021/acsinfecdis.5c00843","title":"Negamycin: Nature’s Forgotten Antibiotic","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Formulary; Drug discovery; Antibiotics; Natural product; Drug; Broad spectrum; Mode of action; Drug development","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005902573,0.0001491099,0.0001304981,0.0000659353,0.0001370608,0.00004410893,0.0001701393,0.0002109628,0.00002656243],"category_scores_gemma":[0.0002551939,0.0001384421,0.0001098269,0.0001334063,0.00004566916,0.000004248038,0.0001036838,0.00008497907,0.0000274656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001406668,"about_ca_system_score_gemma":0.00008578774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001272753,"about_ca_topic_score_gemma":0.00001446947,"domain_scores_codex":[0.9992186,0.00005201687,0.0001255807,0.0003076156,0.00008453989,0.0002115775],"domain_scores_gemma":[0.9994211,0.00002325244,0.00004359728,0.0003856409,0.00005909265,0.0000673242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001447521,0.0004517991,0.1898885,0.0001567364,0.0004180536,0.00001716315,0.00001258039,0.00003870838,0.7160764,0.01455393,0.03109376,0.0471476],"study_design_scores_gemma":[0.000820159,0.0003143465,0.04028391,0.00006887511,0.0001504855,0.00001452508,0.00002780675,0.000006427362,0.8555948,0.008629501,0.0936922,0.0003969839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711927,0.003905769,0.001369176,0.0002518145,0.0006847372,0.0002774269,0.00002816961,0.00008457425,0.02220569],"genre_scores_gemma":[0.9958059,0.0002611541,0.00005139395,0.001619875,0.0001977175,0.00002249323,0.00004916438,0.00001700312,0.00197528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1496046,"threshold_uncertainty_score":0.5645505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003460437251339371,"score_gpt":0.2430321251192382,"score_spread":0.2395716878678988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}