{"id":"W7117325755","doi":"10.1128/spectrum.02511-25","title":"Evaluation of the Bruker MALDI Biotyper (MBT) subtyping module for detection of <i>Klebsiella pneumoniae</i> carbapenemase (KPC) in <i>Enterobacterales</i> in a Canadian clinical microbiology laboratory","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Bacterial Identification and Susceptibility Testing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre; University of British Columbia; Vancouver Coastal Health","funders":"","keywords":"Subtyping; Clinical microbiology; Carbapenem; Infection control; Plasmid; Pathogenic organism; Clinical Practice","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002104738,0.0001378969,0.0002791492,0.0001617507,0.00004855759,0.000007297783,0.0002396276,0.0003655481,0.00001232816],"category_scores_gemma":[0.0005112124,0.0001277605,0.0001210318,0.0002760044,0.0001968258,0.000005276569,0.00007795201,0.0001528943,0.000001638154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001478283,"about_ca_system_score_gemma":0.0007177898,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.007808967,"about_ca_topic_score_gemma":0.4666252,"domain_scores_codex":[0.997906,0.0006678205,0.0006646066,0.0004259193,0.00002505367,0.0003105685],"domain_scores_gemma":[0.9990774,0.00005102213,0.0001991501,0.0004104409,0.0002267926,0.00003522444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007157094,0.0000668195,0.1369535,0.00002549838,0.00002863214,1.447152e-7,0.00002269223,0.00003188923,0.8623786,0.00002544108,0.00009176056,0.0003034325],"study_design_scores_gemma":[0.001422821,0.0001114713,0.1319496,0.00006367735,0.00004892566,0.000007080634,0.00003703101,0.0001842253,0.8600317,0.00008933108,0.005915586,0.0001385443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973903,0.0003272787,0.00003775497,0.0006280789,0.0007384847,0.0006448819,0.0001580716,0.000003986507,0.00007122171],"genre_scores_gemma":[0.9992225,0.00002625454,0.00005774011,0.0003915698,0.00004303343,0.00003240676,0.0001469674,0.00001061224,0.00006890489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4588163,"threshold_uncertainty_score":0.9987981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498108697224246,"score_gpt":0.2863669363370795,"score_spread":0.271385849364837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}