{"id":"W7117325755","doi":"10.1128/spectrum.02511-25","title":"Evaluation of the Bruker MALDI Biotyper (MBT) subtyping module for detection of <i>Klebsiella pneumoniae</i> carbapenemase (KPC) in <i>Enterobacterales</i> in a Canadian clinical microbiology laboratory","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Bacterial Identification and Susceptibility Testing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre; University of British Columbia; Vancouver Coastal Health","funders":"","keywords":"Subtyping; Clinical microbiology; Carbapenem; Infection control; Plasmid; Pathogenic organism; Clinical Practice","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001790213,0.0006777247,0.0004282521,0.001031202,0.0004012163,0.0007470524,0.000950503,0.0005056281,0.000543715],"category_scores_gemma":[0.00434404,0.0004342017,0.0004014156,0.0007134359,0.0005015532,0.0003575287,0.0005582849,0.0003585542,0.0003672459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00110023,"about_ca_system_score_gemma":0.001277131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03778465,"about_ca_topic_score_gemma":0.05041424,"domain_scores_codex":[0.996196,0.0005461429,0.0002673479,0.0005728222,0.002160434,0.0002572502],"domain_scores_gemma":[0.9979767,0.0004798783,0.0003814716,0.00009219384,0.0008034744,0.0002661956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001090059,0.000471883,0.114482,0.000267066,0.0001152221,0.0002460179,0.0005665127,0.0007826634,0.8586139,0.00005862657,0.0003617744,0.02294421],"study_design_scores_gemma":[0.0001234222,0.005927539,0.3222129,0.00004963233,0.0003604635,0.00255766,0.0004551605,0.01582716,0.6500759,0.00002534529,0.002296933,0.00008792497],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995905,0.0003299562,0.00265084,0.00008412288,0.00001092857,0.0001313099,0.0002868703,0.0001621517,0.0004386319],"genre_scores_gemma":[0.985419,0.0001925823,0.01336253,0.00007962892,0.00001017727,0.00005562251,0.0005619162,0.00002158465,0.0002968165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03778465,"threshold_uncertainty_score":0.07512939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498108697224246,"score_gpt":0.2863669363370795,"score_spread":0.271385849364837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}