{"id":"W7117372973","doi":"10.64898/2025.12.23.25342891","title":"Insights into X-Linked Susceptibility to Parkinson’s Disease in the South African Population","year":2025,"lang":"en","type":"article","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Institutes of Health; Michael J. Fox Foundation for Parkinson's Research; Medical Research Council; South African Medical Research Council; National Research Foundation; U.S. Department of Veterans Affairs","keywords":"Locus (genetics); Disease; Quantitative trait locus; Expression quantitative trait loci; Genetic association; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003199413,0.0008271214,0.0007033703,0.001859464,0.0007589369,0.00108043,0.0004429771,0.0006006229,0.005035841],"category_scores_gemma":[0.005746041,0.0003751726,0.00169168,0.003077653,0.0004905117,0.0005300539,0.0009386744,0.0006000798,0.000182404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003025208,"about_ca_system_score_gemma":0.0004807099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005541249,"about_ca_topic_score_gemma":0.006281536,"domain_scores_codex":[0.9985671,0.0007076758,0.0001225576,0.000344781,0.0001402344,0.0001175709],"domain_scores_gemma":[0.9986295,0.000730278,0.0002873616,0.0001676984,0.0001098548,0.00007529169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002380083,0.00008036236,0.9122227,0.00282514,0.02037631,0.001751728,0.002302451,0.001474792,0.01054908,0.002189283,0.001989558,0.04185851],"study_design_scores_gemma":[0.0003328849,0.0002965268,0.9622632,0.0010539,0.01602586,0.001339124,0.001328208,0.001637008,0.00129015,0.00367874,0.01071237,0.00004202509],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478284,0.04207966,0.003957939,0.00169673,0.0001505485,0.00006849161,0.002212839,0.00003125743,0.001974138],"genre_scores_gemma":[0.9934716,0.004446696,0.001132037,0.0002518787,0.00005217015,0.00003430531,0.000356591,0.00001474252,0.0002398289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005541249,"threshold_uncertainty_score":0.01692033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332063533854981,"score_gpt":0.2740739341393912,"score_spread":0.2607532988008414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}