{"id":"W7117448622","doi":"10.1038/s41556-025-01833-4","title":"T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response","year":2025,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; University of British Columbia","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Weill Cornell Medical College; National Institutes of Health; Lady Tata Memorial Trust","keywords":"Germinal center; Embryonic stem cell; Chromatin; Progenitor cell; Epigenetics; Stem cell; Histone; Acquired immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195477,0.0001771521,0.0003479427,0.0002248336,0.0002964912,0.001021524,0.0003971408,0.0003715405,0.001932246],"category_scores_gemma":[0.0004001468,0.0002519517,0.0001978991,0.0001733599,0.0004654836,0.0005824996,0.0006508869,0.001491423,0.0007393535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003098581,"about_ca_system_score_gemma":0.0002055062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002240014,"about_ca_topic_score_gemma":0.0006157001,"domain_scores_codex":[0.9995905,0.00004670874,0.0000202841,0.00006208379,0.00006344796,0.0002170979],"domain_scores_gemma":[0.9995884,0.0001165783,0.00005787976,0.0000665345,0.00002825783,0.0001422859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002718829,0.00001774244,0.0003184353,0.00001917481,0.000003793056,0.00005299537,0.00004390346,0.00003907287,0.997271,0.0002470231,0.00007233391,0.001642632],"study_design_scores_gemma":[0.0001281401,0.0003965461,0.01104998,0.00001645167,0.00003438699,0.0002757343,0.0002701634,0.0009755362,0.9814832,0.000548293,0.004803198,0.00001838694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962512,0.0007866231,0.001042818,0.000131921,0.00009056654,0.000008467349,0.00007802054,0.0001095882,0.001500806],"genre_scores_gemma":[0.9984317,0.0001350055,0.0003391276,0.00006479381,0.00003359107,0.000009014018,0.00007100116,0.00003999102,0.0008757262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001932246,"threshold_uncertainty_score":0.006463945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003158520488065996,"score_gpt":0.2087826956567684,"score_spread":0.2056241751687024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}