{"id":"W7117449343","doi":"10.1158/2326-6066.cir-25-0583","title":"The CCL17–CCR4 Axis Is Critical for Mutant STAT6-Mediated Microenvironmental Remodeling and Therapeutic Resistance in Relapsed/Refractory Diffuse Large B-Cell Lymphoma","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; McGill University; Jewish General Hospital","funders":"Cole Foundation; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada; Cancer Research Society","keywords":"Lymphoma; Infiltration (HVAC); Chemokine; STAT protein; Ex vivo; In vivo; Chemokine receptor; Mutant; Doxorubicin; STAT3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001274857,0.0002997298,0.0001935104,0.0003359956,0.0001550236,0.0003617854,0.0001811137,0.0002934993,0.001410919],"category_scores_gemma":[0.00007102868,0.0001860538,0.0002954468,0.0001347636,0.0003558933,0.0001814506,0.0001444844,0.0007681681,0.0003392897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004412803,"about_ca_system_score_gemma":0.0002602457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005287192,"about_ca_topic_score_gemma":0.0008543766,"domain_scores_codex":[0.9997934,0.00004109134,0.00001855788,0.00002908732,0.0000581355,0.00005975563],"domain_scores_gemma":[0.9998888,0.000008618587,0.00003740863,0.00001096269,0.00000630458,0.00004788604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002605813,0.00006793903,0.0006889877,0.0000198482,0.000004329773,0.00009379155,0.00001172828,0.0001608355,0.9973592,0.0001346367,0.00005213912,0.001145934],"study_design_scores_gemma":[0.0001930429,0.001747151,0.02680912,0.00001542028,0.00004821813,0.002084877,0.0001274253,0.005127458,0.9594693,0.0002340203,0.004128239,0.00001578591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976265,0.0005806502,0.0007288234,0.0001033101,0.00001501346,0.00001567575,0.00024069,0.00004936282,0.0006400332],"genre_scores_gemma":[0.9982327,0.0002341404,0.0004351215,0.00003352735,0.000005368935,0.00001585969,0.0002318761,0.000008885659,0.0008025619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410919,"threshold_uncertainty_score":0.004720032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03310465955174981,"score_gpt":0.3643765976180743,"score_spread":0.3312719380663245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}