{"id":"W7117476920","doi":"10.1158/0008-5472.can-24-2648","title":"C-Terminal Truncation and Fusion Partner Determine Oncogenicity of FGFR3","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Yonsei University College of Medicine; Oncode Institute; KWF Kankerbestrijding; National Research Foundation of Korea; Ministerie van Volksgezondheid, Welzijn en Sport","keywords":"Fibroblast growth factor; Exon; Truncation (statistics); Fibroblast growth factor receptor 3; Fusion gene; Phenotype; Fusion protein; In vivo; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122997,0.0001971344,0.0001759709,0.000236538,0.0001642179,0.0002377209,0.00009754103,0.0003286391,0.001127384],"category_scores_gemma":[0.0003008713,0.0001055157,0.0003310734,0.0002453016,0.0002047034,0.0001318297,0.0001629294,0.0003903669,0.0003771865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703345,"about_ca_system_score_gemma":0.0002252657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043345,"about_ca_topic_score_gemma":0.001356904,"domain_scores_codex":[0.9997686,0.00002657067,0.00003163716,0.00005844503,0.00007176573,0.00004313063],"domain_scores_gemma":[0.9998204,0.00004913134,0.0000651372,0.00002505247,0.00001792133,0.00002240004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001244663,0.00001199356,0.003104744,0.00001442118,0.00001182313,0.0001645937,0.00001062411,0.0001566609,0.9953483,0.00005024455,0.00003279697,0.0009693856],"study_design_scores_gemma":[0.00002518485,0.0002205534,0.0654416,0.000007146891,0.00006893649,0.005695245,0.00005933432,0.002044902,0.9222137,0.0001312677,0.004078924,0.0000132559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973831,0.0002376231,0.001055961,0.00003253753,0.000004688683,0.00001149194,0.0007572804,0.00002168612,0.000495795],"genre_scores_gemma":[0.9976948,0.000111557,0.0007295406,0.00003368904,0.000002169368,0.000007672747,0.001091971,0.00001109315,0.0003175403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127384,"threshold_uncertainty_score":0.003771484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05066013110091243,"score_gpt":0.4230960400528441,"score_spread":0.3724359089519316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}