{"id":"W7117476920","doi":"10.1158/0008-5472.can-24-2648","title":"C-Terminal Truncation and Fusion Partner Determine Oncogenicity of FGFR3","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Yonsei University College of Medicine; Oncode Institute; KWF Kankerbestrijding; National Research Foundation of Korea; Ministerie van Volksgezondheid, Welzijn en Sport","keywords":"Fibroblast growth factor; Exon; Truncation (statistics); Fibroblast growth factor receptor 3; Fusion gene; Phenotype; Fusion protein; In vivo; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005477074,0.00008004417,0.0001132727,0.0001510939,0.00009753441,0.00001975491,0.0002017729,0.0001113843,0.00006366896],"category_scores_gemma":[0.0001997215,0.00007301164,0.00003615555,0.0002632861,0.0002880394,0.000004588441,0.000345844,0.0001760524,0.000003497313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005022112,"about_ca_system_score_gemma":0.0003693543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002101667,"about_ca_topic_score_gemma":0.0001489455,"domain_scores_codex":[0.9987919,0.0001599291,0.0001571238,0.000307928,0.0002926463,0.0002904382],"domain_scores_gemma":[0.9992273,0.0000483078,0.00002772324,0.0003008659,0.0003210283,0.00007474146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002719083,0.0000317079,0.01073645,0.0001352575,0.00001993834,0.000001846561,0.00003347117,0.00000252614,0.9713002,0.00009567229,0.002290443,0.01508055],"study_design_scores_gemma":[0.000472242,0.0002630341,0.03028294,0.00007420841,0.000005114667,0.000003112932,0.00003838355,0.00007709298,0.9525468,0.0001379134,0.01602591,0.00007325243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969841,0.001086765,0.00009958933,0.0003382249,0.00004600151,0.0002440595,0.00001747591,0.000004045546,0.001179757],"genre_scores_gemma":[0.9954832,0.0005474985,0.00007783255,0.00003039583,0.00008331271,0.00007627604,0.00002245815,0.00001010063,0.003668881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01954649,"threshold_uncertainty_score":0.2977328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05066013110091243,"score_gpt":0.4230960400528441,"score_spread":0.3724359089519316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}