{"id":"W7117484199","doi":"10.1093/pnasnexus/pgaf406","title":"Soluble CD14 promotes Th17 expansion and differentiation through gamma-aminobutyric acid and expands non-canonical innate lymphoid cells","year":2025,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; Northern Alberta Institute of Technology; Women and Children’s Health Research Institute; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Innate lymphoid cell; CD14; Chemokine; Innate immune system; Cytokine; Immune system; Peripheral blood mononuclear cell; Cellular differentiation; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146283,0.0002639919,0.0003575417,0.000102846,0.0003035916,0.00004727131,0.0001140959,0.0003115736,0.00008153402],"category_scores_gemma":[0.00002792678,0.0002169454,0.00006551466,0.0001596402,0.0001389855,0.0001637529,0.0001557709,0.0001196282,0.00005817651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004240061,"about_ca_system_score_gemma":0.00007500619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001007636,"about_ca_topic_score_gemma":0.00003421225,"domain_scores_codex":[0.9987447,0.0001290019,0.000266357,0.0004572567,0.00004017937,0.0003624644],"domain_scores_gemma":[0.9994431,0.0001335025,0.00009206702,0.0002578361,0.00004421632,0.00002933844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002499073,0.0002527716,0.01611588,0.00007719995,0.0003121692,0.000007820869,0.001253088,9.420702e-7,0.9388014,0.000400336,0.001059649,0.04146883],"study_design_scores_gemma":[0.004172219,0.000271366,0.04429476,0.00008842973,0.0003381598,0.00003382672,0.0001929304,0.00006343432,0.9449317,0.001080733,0.004226046,0.0003063524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985571,0.0104746,0.0004360226,0.0001896343,0.001132496,0.0003387748,0.0000242701,0.0000727215,0.001760531],"genre_scores_gemma":[0.9937365,0.001129345,0.0001512496,0.0001099737,0.00003941085,0.00006741761,0.0001376529,0.00001567319,0.004612764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04116248,"threshold_uncertainty_score":0.8846778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282553479672448,"score_gpt":0.237415518341559,"score_spread":0.2245899835448345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}