{"id":"W7117485440","doi":"10.3390/cells15010056","title":"Integration of cAMP and TRPV4 Signaling to Optimize Collagen Remodeling for Management of Fibrosis","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"TRPV4; Myofibroblast; Fibrosis; Signal transduction; G protein-coupled receptor; Extracellular matrix; Receptor; Mechanosensitive channels; Cyclic adenosine monophosphate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439888,0.00005231892,0.00009323061,0.00005091358,0.00002199688,0.000006092559,0.00007164585,0.00003873322,0.000006066609],"category_scores_gemma":[0.0000300724,0.00005239249,0.00003287468,0.00008159424,0.00001821207,0.000001266568,0.00008374659,0.00001239034,3.354033e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009640078,"about_ca_system_score_gemma":0.0000216829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001373756,"about_ca_topic_score_gemma":0.000003716402,"domain_scores_codex":[0.9995673,0.00001700556,0.0001266048,0.0001557815,0.00005006258,0.00008327102],"domain_scores_gemma":[0.9996851,0.00002549998,0.00002896627,0.0001240305,0.000113469,0.00002292684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132254,0.00001197988,0.00002857798,0.000158543,0.00003915206,1.399955e-7,0.0000472974,0.000817179,0.9910008,0.0001553467,0.0002242282,0.007384538],"study_design_scores_gemma":[0.0002879317,0.0001159521,0.0001352937,0.00007658493,0.00001753886,8.465221e-8,0.0002097743,0.0008156284,0.9968908,0.00008085438,0.001324925,0.00004458883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8636722,0.0003376192,0.134763,0.00005224865,0.00003296077,0.0004543631,0.00002265799,0.000001968462,0.0006630255],"genre_scores_gemma":[0.9763005,0.00005067847,0.02285172,0.00001638761,0.000009953033,0.00002438628,0.00001453668,0.000005585589,0.0007262156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1126283,"threshold_uncertainty_score":0.2136503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988153176839079,"score_gpt":0.3104360979974387,"score_spread":0.2905545662290479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}