{"id":"W7117530585","doi":"10.1016/j.celrep.2025.116840","title":"Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Montreal Clinical Research Institute; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Université de Montréal; Institut de Recherche Clinique De Montréal; Leukemia and Lymphoma Society of Canada; Canadian Institutes of Health Research; Cancer Research Society; Merck","keywords":"Angiogenesis; CXCL10; Chemokine; Immune system; Endothelial stem cell; Neovascularization; Kinase; CCL2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424487,0.0004030431,0.0002596957,0.0002075312,0.0001512084,0.0003697493,0.0002214307,0.0002525746,0.001642171],"category_scores_gemma":[0.00009989706,0.0001454687,0.0002134337,0.0001766403,0.000318481,0.0002470199,0.0001516556,0.0009602947,0.0004227691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022794,"about_ca_system_score_gemma":0.0002863606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000488466,"about_ca_topic_score_gemma":0.0007723785,"domain_scores_codex":[0.9998336,0.00003361803,0.00001645254,0.00002325799,0.00003274183,0.00006031472],"domain_scores_gemma":[0.9999146,0.00001436244,0.00002116095,0.00001189308,0.000006272656,0.00003157646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002842698,0.0001131137,0.0001310936,0.00005681076,0.000008873292,0.00004469367,0.00001252941,0.0001544483,0.9969004,0.0002593035,0.0001758722,0.001858607],"study_design_scores_gemma":[0.00006461278,0.000639386,0.001914275,0.000005829259,0.00001724682,0.0002777701,0.00002934899,0.002100497,0.9910219,0.00007554489,0.003849181,0.000004361851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922507,0.001227907,0.003056892,0.0002671346,0.00005560928,0.00003030684,0.0004252545,0.0001868371,0.00249943],"genre_scores_gemma":[0.9944659,0.0007190645,0.001520253,0.00006673808,0.00001191226,0.00004908551,0.0004313669,0.00002318949,0.002712706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642171,"threshold_uncertainty_score":0.005493581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005812841481704942,"score_gpt":0.2300725693027798,"score_spread":0.2242597278210748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}