{"id":"W7117537090","doi":"10.20935/acadonco8089","title":"Targeting DNA repair in lung cancer with PARP inhibitors","year":2025,"lang":"en","type":"article","venue":"Academia oncology.","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Lung cancer; Context (archaeology); Treatment of lung cancer; PARP inhibitor; DNA repair; Poly ADP ribose polymerase; Synthetic lethality; DNA Damage Repair; Acquired resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005510891,0.0001920483,0.0004577215,0.0002590333,0.00007640589,0.000003636669,0.000108498,0.0007625363,0.0002406449],"category_scores_gemma":[0.0001303944,0.0001618045,0.00007324423,0.0007310947,0.0001734508,0.0001049358,0.00005003539,0.001664519,0.00001217521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001572397,"about_ca_system_score_gemma":0.001089352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001616488,"about_ca_topic_score_gemma":0.00008190875,"domain_scores_codex":[0.9983346,0.0001122071,0.000486861,0.0004305741,0.0002116178,0.0004240671],"domain_scores_gemma":[0.9992397,0.0002142401,0.0001447189,0.0002113862,0.00008424369,0.0001056995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001098997,0.00014236,0.6410119,0.0002379344,0.000206447,0.0001757648,0.0008356337,0.0002615742,0.01793783,0.0006123786,0.3318466,0.005632546],"study_design_scores_gemma":[0.01237027,0.0005108414,0.07837362,0.002366626,0.0002607819,0.00004921053,0.0007168301,0.001569908,0.0310058,0.0003810713,0.8719361,0.000458927],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9360883,0.007873307,0.0001282057,0.03621649,0.0007389536,0.0009819012,0.00001397592,0.000364149,0.01759471],"genre_scores_gemma":[0.9676239,0.001791699,0.001974917,0.02357939,0.0007087783,0.000731622,0.00001902277,0.00004105015,0.003529565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5626383,"threshold_uncertainty_score":0.72316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013611364587404,"score_gpt":0.3685691704640547,"score_spread":0.3549578058766507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}