{"id":"W7117537090","doi":"10.20935/acadonco8089","title":"Targeting DNA repair in lung cancer with PARP inhibitors","year":2025,"lang":"en","type":"article","venue":"Academia oncology.","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Lung cancer; Context (archaeology); Treatment of lung cancer; PARP inhibitor; DNA repair; Poly ADP ribose polymerase; Synthetic lethality; DNA Damage Repair; Acquired resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007040848,0.000466488,0.0007289498,0.0008457788,0.0002499066,0.000917296,0.0005722471,0.0007702986,0.001724945],"category_scores_gemma":[0.0005300129,0.0002120309,0.0005641634,0.0005864204,0.0003770898,0.001027363,0.0005724612,0.001757727,0.001045946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005477024,"about_ca_system_score_gemma":0.0005551894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004131186,"about_ca_topic_score_gemma":0.001217122,"domain_scores_codex":[0.9997115,0.0000768779,0.0000343715,0.00004358365,0.0001006118,0.0000331852],"domain_scores_gemma":[0.9998088,0.00007696595,0.00004476579,0.000008326047,0.00004670447,0.00001440471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003914595,0.0002160529,0.0006789273,0.01959652,0.0002335077,0.001116243,0.0002334572,0.002450612,0.04116029,0.01738851,0.03435741,0.882177],"study_design_scores_gemma":[0.00008328338,0.0009932677,0.001521242,0.002616337,0.000194039,0.004499002,0.00009197222,0.0008432496,0.01761544,0.005866386,0.9656365,0.00003930099],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001642831,0.9915802,0.001686103,0.001051679,0.0003324687,0.00002929803,0.0000467667,0.0000285529,0.003602023],"genre_scores_gemma":[0.01547205,0.9797497,0.001554117,0.0007757134,0.0004349646,0.00003468811,0.0001096875,0.00000604866,0.001863103],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001724945,"threshold_uncertainty_score":0.005770564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013611364587404,"score_gpt":0.3685691704640547,"score_spread":0.3549578058766507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}