{"id":"W7117546271","doi":"10.1111/exd.70191","title":"Mimicking Darier Disease In Vitro: A Human Epidermal Organoid Approach","year":2025,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Genetic and rare skin diseases.","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Universität Basel","keywords":"Darier's disease; Organoid; Keratinocyte; Phenotype; Darier Disease; Epidermis (zoology); Transcriptome; Disease; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003715987,0.0001988803,0.0002100133,0.00009847293,0.0001234021,0.00002045055,0.0002408198,0.0001436185,0.0000707221],"category_scores_gemma":[0.00002382833,0.0002051617,0.00009835424,0.0001072153,0.0001913667,0.00000333052,0.0002639879,0.00009125033,0.00001236422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002735624,"about_ca_system_score_gemma":0.0001121833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002912575,"about_ca_topic_score_gemma":0.000003168178,"domain_scores_codex":[0.9987223,0.0001137222,0.0002664673,0.0004680011,0.00007835196,0.0003511749],"domain_scores_gemma":[0.9994471,0.000006442066,0.00004370665,0.0003579689,0.00001873127,0.0001260483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002153558,0.0005025254,0.01985076,0.00003915499,0.00004479379,0.00008516121,0.0001025538,0.0000312283,0.9734167,0.0006587877,0.004857828,0.0001951176],"study_design_scores_gemma":[0.001307781,0.00002218294,0.01882278,0.000009249989,0.00001656722,0.0000536929,0.0003236081,0.0001395005,0.9711348,0.0001367993,0.007770139,0.0002628452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980361,0.006882624,0.0005810795,0.0002231733,0.0002009344,0.0002693452,0.00001320472,0.00002227095,0.0114464],"genre_scores_gemma":[0.997213,0.00001322609,0.0006243772,0.001067855,0.00005228896,0.0001047917,0.000336913,0.00002008866,0.0005674589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01685203,"threshold_uncertainty_score":0.836625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006359028590075712,"score_gpt":0.2703082607373671,"score_spread":0.2639492321472914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}