{"id":"W7117546271","doi":"10.1111/exd.70191","title":"Mimicking Darier Disease In Vitro: A Human Epidermal Organoid Approach","year":2025,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Genetic and rare skin diseases.","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Universität Basel","keywords":"Darier's disease; Organoid; Keratinocyte; Phenotype; Darier Disease; Epidermis (zoology); Transcriptome; Disease; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005832704,0.0004574685,0.0004269587,0.0004554125,0.0004146949,0.0007236304,0.0003838339,0.000782221,0.002125113],"category_scores_gemma":[0.0002506392,0.0002403533,0.0006154971,0.0003415688,0.0003319843,0.0003621286,0.000632882,0.001116052,0.001596596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003223074,"about_ca_system_score_gemma":0.0002788757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007847,"about_ca_topic_score_gemma":0.001845846,"domain_scores_codex":[0.9995753,0.0001111486,0.00003649788,0.0001102512,0.0001138052,0.00005304751],"domain_scores_gemma":[0.999708,0.00009237167,0.00003093535,0.00008732413,0.00003679572,0.00004444129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001265177,0.00007892468,0.0003262439,0.0001296427,0.00001576997,0.0005303102,0.00015845,0.0006095591,0.9950069,0.0005726605,0.0002492008,0.002195765],"study_design_scores_gemma":[0.00003777295,0.001014447,0.002922916,0.00004955199,0.00006854842,0.002837641,0.0004385809,0.003973665,0.9620491,0.000493632,0.02607372,0.0000405238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8473626,0.01013534,0.1110907,0.0006802459,0.0006235543,0.001242715,0.005655748,0.0006845208,0.02252463],"genre_scores_gemma":[0.9475644,0.004878862,0.03556,0.0003024667,0.00002491748,0.0004722186,0.003521199,0.00009026066,0.007585587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002125113,"threshold_uncertainty_score":0.007109225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006359028590075712,"score_gpt":0.2703082607373671,"score_spread":0.2639492321472914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}